Pharmacy Department, Centre for PG Studies and Research, The M.S. University of Baroda, Vadodara, Gujarat, India.
Crit Rev Ther Drug Carrier Syst. 2011;28(5):447-88. doi: 10.1615/critrevtherdrugcarriersyst.v28.i5.20.
The interest in the preparation and application of nanometer-sized materials is increasing due to their tremendous potential as a drug delivery system with wide range of applications. Recently, nanoscale systems have received much interest as a way to resolve solubility issues because of their cost-effectiveness and technical simplicity compared to liposomes and other colloidal drug carriers. Nanosuspensions have proven to be a better alternative over other approaches currently available for improving bioavailability of number of drugs with low solubility. Nanosuspensions have been extensively developed for a wide range of drugs and have been evaluated for in vitro and in vivo applications by various routes: parenteral, oral, pulmonary, topical. They have also been used for drug targeting. Different preparation methods for nanosuspensions and their application are being reported and patented. In fact, the number of products based on nanosuspension in the market and under clinical study is higher than that of other nanotechnology-based applications. This article reviews the research and recent advances in formulation, characterization, application of nanosuspensions as well as patents on nanosuspension methods.
由于纳米材料作为药物输送系统具有广泛的应用前景，因此其制备和应用引起了极大的关注。最近，纳米级系统因其成本效益和技术简单性而受到关注，与脂质体和其他胶体药物载体相比，纳米级系统是解决溶解度问题的一种方法。与目前提高低溶解度药物生物利用度的其他方法相比，纳米混悬剂已被证明是一种更好的选择。已经为广泛的药物开发了纳米混悬剂，并通过各种途径（包括：肠胃外、口服、肺部、局部）对其进行了体外和体内应用的评估。它们还被用于药物靶向。正在报道和专利纳米混悬剂的不同制备方法及其应用。事实上，市场上和临床研究中基于纳米混悬剂的产品数量高于其他基于纳米技术的应用。本文综述了纳米混悬剂的制剂、表征、应用的研究和最新进展，以及纳米混悬剂方法的专利。
