Agarwal Vijay, Bajpai Meenakshi
College of Pharmaceutical Sciences, Rajkumar Goel Institute of Technology, 5-Km. Stone, Delhi- Meerut Road, Ghaziabad (U.P)-201003; India.
Recent Pat Nanotechnol. 2015;9(3):178-94. doi: 10.2174/1872210510999151126112644.
Nowadays, in pharmaceutical industries, the attention on nanosized materials is growing gradually due to their wide applications in drug delivery systems. Recently, out of different nanosize systems, nanosuspension system has undergone a lot of interest in such a way to rectify the solubility and bioavailability problem due to their technical simplicity and cost-effectiveness property compared to other colloidal systems. Nanosuspension technology has proven that it can be a superior substitute over alternative approaches, which are available for enhancing the bioavailability of different drugs having low solubility. Since today, nanosuspensions have been greatly evolved for a huge number of drugs and also investigated for their potential applications. The various unique features make the nanosuspension to enable their utilization in numerous dosage forms and given through different routes, including parenteral, oral, topical, peroral, ocular and pulmonary routes. A large number of products grounded in nanosuspension technology are present in the market, and some are on the way. In fact, the number of such types of products is much more in comparison of other nanotechnologies based products. Additionally, the different preparation methods used to prepare the nanosuspensions are also well- established and patented. This article reviews the recent research, advances in formulation and their approaches related to nanosuspensions with emphasis given on different patents related to nanosuspension methods.
如今，在制药行业，由于纳米材料在药物递送系统中的广泛应用，对其的关注度正在逐渐提高。最近，在不同的纳米尺寸系统中，纳米混悬液系统因其技术简单且具有成本效益，相对于其他胶体系统，在解决溶解度和生物利用度问题方面受到了广泛关注。纳米混悬液技术已证明，与其他可用于提高低溶解度不同药物生物利用度的替代方法相比，它是一种更优越的替代方法。从现在起，纳米混悬液已在大量药物中得到了极大的发展，并对其潜在应用进行了研究。纳米混悬液的各种独特特性使其能够用于多种剂型，并通过不同途径给药，包括肠胃外、口服、局部、经口、眼部和肺部途径。市场上有大量基于纳米混悬液技术的产品，还有一些正在研发中。事实上，与其他基于纳米技术的产品相比，这类产品的数量要多得多。此外，用于制备纳米混悬液的不同制备方法也已成熟并获得专利。本文综述了纳米混悬液的最新研究、制剂进展及其相关方法，重点介绍了与纳米混悬液方法相关的不同专利。
