Jethara Sahilhusen I, Patel Alpesh D, Patel Mukesh R, Patel Mukesh S, Patel Kanu R
Department of Pharmaceutics, Shri B. M. Shah College of Pharmaceutical Education and Research, College Campus, Modasa -383315, Gujarat, India.
Recent Pat Drug Deliv Formul. 2015;9(1):65-78. doi: 10.2174/1872211308666141028214003.
The major goals of designing nanosuspension of nanosize materials are increasing due to their tremendous potential as a drug delivery system with the wide range of applications. Nanosuspension is a unique tool for improving the bioavailability of poorly soluble drugs. Nanosuspension drug delivery has wide range of application like oral, injectable, transdermal, inhalation, peroral, ocular, pulmonary and topical etc. by improviing the bioavailability, reducing the dose, gastric irritation, decreasing intra subject variability and increasing adhesivness with intestinal membrane. Recently, nanosuspension has been received much interest as a way to resolve solubility and stability problem because of their cost-effectiveness and technical simplicity compare to other liposome and colloidal drug carriers. Nanosuspensions are engaged to control particle size, surface properties and release of pharmacologically active agents in order to achieve the site-specific action of the drug at the therapeutically optimal rate, improve the bioavaibility of drug with poor solubility and dose regimen. Application and preparation method of nanosuspension has been reported by research articles and patented in different countries. Most of the marketed nanosuspensions are in preclinical and clinical based study for its application. More than 100 patents have been published on nanosuspensions by the recent days. This patent reviews covers different methods of pharmaceutical preparation and applications in drug delivery as well as the recent marketed published or granted patent surveys. This patent review is useful in enhance the knowledge of controlled drug delivery and applications.
由于纳米材料作为药物递送系统具有巨大潜力且应用广泛，设计纳米尺寸材料的纳米混悬液的主要目标不断增加。纳米混悬液是提高难溶性药物生物利用度的独特工具。纳米混悬液药物递送通过提高生物利用度、降低剂量、减少胃部刺激、降低个体内变异性以及增加与肠膜的黏附性等，在口服、注射、透皮、吸入、经口、眼部、肺部和局部等方面有广泛应用。最近，纳米混悬液作为解决溶解度和稳定性问题的一种方式受到了广泛关注，因为与其他脂质体和胶体药物载体相比，它们具有成本效益且技术简单。纳米混悬液用于控制粒径、表面性质和药理活性剂的释放，以实现药物在治疗最佳速率下的位点特异性作用，提高难溶性药物的生物利用度和给药方案。纳米混悬液的应用和制备方法已在研究文章中报道，并在不同国家获得专利。大多数市售纳米混悬液正处于基于临床前和临床的应用研究阶段。近年来已发表了100多项关于纳米混悬液的专利。本专利综述涵盖了药物制剂的不同方法及其在药物递送中的应用，以及最近市售产品的已发表或已授予的专利调查。本专利综述有助于增强对控释药物递送及其应用的了解。
