（±）-米非恩辛的简洁全合成。
A concise total synthesis of (±)-minfiensine.
机构信息
Laboratory of Molecular Engineering, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China.
出版信息
Org Lett. 2011 Dec 16;13(24):6426-8. doi: 10.1021/ol2027224. Epub 2011 Nov 11.
PMID:22077333
Abstract
A concise total synthesis of (±)-minfiensine using all conventional methods and starting from commercial materials has been completed. The synthesis features a Fischer indole synthesis, a Heck alkylation of an intermediate ketone enolate, conversion of a ketone carbonyl into an epoxide, and transformation of the latter into an allylic alcohol.
摘要
采用全常规方法并从商业原料出发，完成了（±）-minfiensine 的简洁全合成。该合成方法的特点是 Fischer 吲哚合成、中间体酮烯醇的 Heck 烷基化、将酮羰基转化为环氧化物以及将后者转化为烯丙醇。
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