Department of Dermatology, Mahidol University, Bangkok 10700, Thailand.
Contact Dermatitis. 2011 Dec;65(6):311-6. doi: 10.1111/j.1600-0536.2011.01978.x.
Contact allergy to cosmetic ingredients is common. However, there are no recent comprehensive studies on contact allergy to cosmetic ingredients in Asia.
To identify positive patch test reactions in patients tested at Siriraj Hospital, Bangkok, Thailand to allergens present in cosmetics.
A retrospective review of medical records from the outpatient contact dermatitis clinic was conducted from January 1999 to December 2008. Patients with at least one positive patch test reaction to allergens associated with cosmetic ingredients were studied. The results were evaluated using Pearson's χ(2) -test with Yates' continuity correction or Fisher's exact test where appropriate,and a p-value <0.002 was considered to be statistically significant by Bonferroni correction.
There were 1247 cases (239 males and 1008 females; mean age 38.5 years). Fragrance chemicals and preservatives were the most commonly recognized cosmetic allergens. Ammoniated mercury was the only allergen that showed a significantly increased frequency over the 10-year period (p = 0.0008).
Our study showed that ammoniated mercury is an emerging cosmetic allergen, showing an increased prevalence in recent years in Thailand. A focus is required on emerging cosmetic allergens and what may account for the upward trend of cosmetic contact dermatitis.
化妆品成分引起的接触过敏很常见。然而，亚洲目前还没有关于化妆品成分接触过敏的综合研究。
鉴定在泰国曼谷 Siriraj 医院接受测试的患者对化妆品中存在的变应原的阳性斑贴试验反应。
对 1999 年 1 月至 2008 年 12 月间门诊接触性皮炎诊所的病历进行回顾性研究。研究对象为对与化妆品成分相关的变应原至少有一次阳性斑贴试验反应的患者。使用 Pearson's χ(2) -test 与 Yates'连续性校正或 Fisher's 确切检验（视情况而定）进行评估，如果 Bonferroni 校正后 p 值<0.002，则认为具有统计学意义。
共有 1247 例患者（男 239 例，女 1008 例；平均年龄 38.5 岁）。香料化学品和防腐剂是最常见的化妆品过敏原。氨汞是唯一在 10 年期间显示出频率显著增加的变应原（p = 0.0008）。
我们的研究表明，氨汞是一种新兴的化妆品过敏原，近年来在泰国的流行率有所上升。需要关注新兴的化妆品过敏原以及可能导致化妆品接触性皮炎上升的原因。
