Belanger J G, Blair I G, Elder A M, Fox A J, Goldenberg M H, Mason J T, Nugent R A
Department of Radiology, Ottawa Civic Hospital, Ontario.
Can Assoc Radiol J. 1990 Aug;41(4):191-4.
An open, multicenter trial of adult myelography was carried out at six centers in 117 patients with iohexol (Omnipaque) 240 mg I/ml and 300 mg I/ml to determine whether there was a difference in visualization or side-effects when a lumbar or cervical approach was used to visualize the areas where disease was suspected. One hundred and thirteen myelograms were analysable. In over 85% of the myelograms with a lumbar approach, visualization of the area injected was excellent or good. Just over half of these were obtained with the intention of visualizing primarily the cervical area, and in 93% of these visualization was good or excellent at that site. In 100% of the cervically injected myelograms, visualization was excellent in the cervical area. Areas more distant from the injections were well visualized in the majority of patients. There was no significant difference overall in visualization with either of the two concentrations of iohexol used. There were 59 side-effects, mostly mild in nature; 40 of them occurred in 50 patients receiving the higher concentration and 19 in 63 patients receiving the lower concentration. The most common side-effect was headache (23 patients). Nystagmus was the only severe side-effect and occurred in only one patient having cervical myelography. The patient made a complete recovery within 36 hours.
在六个中心对117名成人进行了一项开放式多中心脊髓造影试验，使用碘海醇（欧乃派克）240mgI/ml和300mgI/ml，以确定当采用腰椎或颈椎入路来观察疑似病变区域时，在显影效果或副作用方面是否存在差异。113份脊髓造影片可供分析。在超过85%的腰椎入路脊髓造影片中，注射区域的显影效果为优或良。其中略超过一半的造影片主要目的是观察颈椎区域，其中93%在该部位的显影效果为良或优。在100%的颈椎注射脊髓造影片中，颈椎区域的显影效果为优。在大多数患者中，远离注射部位的区域也能得到良好显影。所使用的两种浓度碘海醇在总体显影效果上无显著差异。共有59例副作用，大多性质轻微；其中40例发生在50名接受较高浓度碘海醇的患者中，19例发生在63名接受较低浓度碘海醇的患者中。最常见的副作用是头痛（23例患者）。眼球震颤是唯一的严重副作用，仅发生在1例进行颈椎脊髓造影的患者中。该患者在36小时内完全康复。
