Latchaw R E, Sackett J F, Turski P A, Shaw D D
AJNR Am J Neuroradiol. 1985 Nov-Dec;6(6):927-30.
Cervical myelography with iohexol via C1-C2 puncture was performed in 30 patients in two medical centers using a concentration of 240 mg l/ml. The study demonstrated iohexol to be a safe contrast medium without significant changes in neurologic and physical examination, vital signs, electrocardiogram, or hematologic or blood chemistry parameters. Fifteen patients had electroencephalograms (EEGs); two were abnormal. In one patient the baseline EEG demonstrated nonspecific slow waves in the temporal regions bilaterally that remained unchanged after myelography. In the second patient, transient changes in the left hemisphere during either hyperventilation or photic stimulation on postmyelographic EEG had not been present on the baseline recording. The relation of these changes to the drug remains unclear. Iohexol was found to be an efficacious myelographic contrast agent, with good to excellent myelograms in 93% of cases. Headache occurred in 13% and nausea in 3%.
在两个医疗中心，对30例患者经C1-C2穿刺注入碘海醇进行颈椎脊髓造影，碘海醇浓度为240mgI/ml。研究表明，碘海醇是一种安全的造影剂，在神经和体格检查、生命体征、心电图、血液学或血液化学参数方面无显著变化。15例患者进行了脑电图（EEG）检查，其中2例异常。1例患者基线脑电图显示双侧颞区非特异性慢波，脊髓造影后无变化。第2例患者，脊髓造影后脑电图在过度换气或闪光刺激时左半球的短暂变化在基线记录中未出现。这些变化与药物的关系尚不清楚。碘海醇被发现是一种有效的脊髓造影造影剂，93%的病例脊髓造影显示良好至极佳。13%的患者出现头痛，3%的患者出现恶心。
