Burrows E H
AJNR Am J Neuroradiol. 1985 May-Jun;6(3):349-51.
The side effects of iohexol were evaluated in the 300 patients who had nonemergency myelography over a 9 month period. No patients studied with myelography were excluded from the iohexol trial. Age range was 14-86 years. Introduction was by lumbar puncture in 206 patients and by lateral C1-C2 injection in 94. Side effects, including discomfort, were denied by 81.3% of the patients. The other 18.7% had adverse reactions, the most common being headache, reported by 11% of the total population studied. Image quality was judged unsatisfactory in 8.1% of cervical myelograms and in 2.6% of lumbar myelograms. With lumbar injection, cervical myelograms were judged to be inadequate in 13.5%; with cervical injection, lumbar myelograms were inadequate in 25%. Iohexol caused significantly fewer side effects in the 300 patients than would have been expected with metrizamide. The low cost and ease of use are additional factors that favor iohexol as the contrast agent of choice for myelography.
在9个月的时间里，对300例接受非急诊脊髓造影的患者进行了碘海醇副作用的评估。接受脊髓造影检查的患者均未被排除在碘海醇试验之外。年龄范围为14至86岁。206例患者通过腰椎穿刺注入造影剂，94例通过C1 - C2外侧注射。81.3%的患者否认有包括不适在内的副作用。其余18.7%的患者有不良反应，最常见的是头痛，占所研究总人口的11%。8.1%的颈椎脊髓造影和2.6%的腰椎脊髓造影图像质量被判定为不满意。腰椎注射时，13.5%的颈椎脊髓造影被判定为不充分；颈椎注射时，25%的腰椎脊髓造影不充分。与甲泛葡胺相比，碘海醇在这300例患者中引起的副作用明显更少。低成本和使用方便是碘海醇作为脊髓造影首选造影剂的额外优势。
