Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Virology. 2012 Jan 5;422(1):151-60. doi: 10.1016/j.virol.2011.10.016. Epub 2011 Nov 10.
Swine influenza viruses (SIV) have been recognized as important pathogens for pigs and occasional human infections with swine origin influenza viruses (SOIV) have been reported. Between 1990 and 2010, a total of twenty seven human cases of SOIV infections have been identified in the United States. Six viruses isolated from 1990 to 1995 were recognized as classical SOIV (cSOIV) A(H1N1). After 1998, twenty-one SOIV recovered from human cases were characterized as triple reassortant (tr_SOIV) inheriting genes from classical swine, avian and human influenza viruses. Of those twenty-one tr_SOIV, thirteen were of A(H1N1), one of A(H1N2), and seven of A(H3N2) subtype. SOIV characterized were antigenically and genetically closely related to the subtypes of influenza viruses circulating in pigs but distinct from contemporary influenza viruses circulating in humans. The diversity of subtypes and genetic lineages in SOIV cases highlights the importance of continued surveillance at the animal-human interface.
猪流感病毒（SIV）已被确认为猪的重要病原体，偶尔也会有猪源流感病毒（SOIV）感染人类的报道。1990 年至 2010 年期间，美国共确认了 27 例 SOIV 感染病例。1990 年至 1995 年分离出的 6 株病毒被认为是经典的 SOIV（cSOIV）A(H1N1)。1998 年后，从人类病例中分离出的 21 株 SOIV 被鉴定为三重重组（tr_SOIV），继承了经典猪流感病毒、禽流感病毒和人流感病毒的基因。在这 21 株 tr_SOIV 中，有 13 株为 A(H1N1)，1 株为 A(H1N2)，7 株为 A(H3N2)亚型。鉴定的 SOIV 在抗原性和遗传上与猪中流行的流感病毒亚型密切相关，但与当时在人群中流行的流感病毒不同。SOIV 病例中亚型和遗传谱系的多样性突出表明，需要在动物与人类的接触界面继续进行监测。
