2020年至2023年期间在巴西检测到的新型甲型流感变异病毒的人畜共患传播。

Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023.

作者信息

Resende Paola Cristina, Junqueira Dennis M, Tochetto Caroline, Ogrzewalska Maria, Motta Fernando C, Lopes Jonathan, Appolinario Luciana, Macedo Larissa, Caetano Braulia, Matos Aline, Silva Thauane, Pereira Elisa Cavalcante, Lima Leticia Ferreira, Riediger Irina, Debur Maria do Carmo, Becker Guilherme Nardi, Andrade Aline, Nasr Acácia Maria Lourenço Francisco, Piler Rosana Aparecida, Dalla Vecchia Ana Carolina, Almeida Walquíria, Brown David, Schaefer Rejane, Siqueira Marilda M

机构信息

Laboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz Foundation, Fiocruz, Rio de Janeiro, Brazil.

Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Laboratório de Bioinformática e Evolução Viral, Universidade Federal de Santa Maria (UFSM), Santa Maria, Santa Catarina, Brazil.

出版信息

Nat Commun. 2024 Dec 30;15(1):10748. doi: 10.1038/s41467-024-53815-z.

Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild and 2 severe cases, including 1 death) detected in Paraná, Brazil, during 2020-2023. Genomes recovered were closely related to Brazilian swIAVs of three major lineages (1 A.3.3.2/pdm09, 1B/human-like, and H3.1990.5), including three H1N1v, two H1N2v, two H3N2v and one H1v. Five H1v were closely related to pdm09 lineage, one H1v (H1N2v) grouped within 1B.2.3 clade, and the two H3v grouped within a clade composed exclusively of Brazilian H3 swIAV (clade H3.1990.5.1). Internal gene segments were closely related to H1N1pdm09 isolated from pigs. IAV variant rarely result in sustained transmission between people, however the potential to develop such ability is of concern and must not be underestimated. This study brings into focus the need for continuous influenza surveillance and timely risk assessment.

甲型流感病毒（IAV）引起的人畜共患感染（猪传人）已有报道，且与这些物种之间的密切接触有关。在此，我们描述了2020年至2023年期间在巴西巴拉那州检测到的8例人类IAV变异株感染病例（6例轻症和2例重症，包括1例死亡）。 recovered的基因组与巴西三种主要谱系的猪IAV密切相关（1 A.3.3.2/pdm09、1B/类人型和H3.1990.5），包括3株H1N1v、2株H1N2v、2株H3N2v和1株H1v。5株H1v与pdm09谱系密切相关，1株H1v（H1N2v）归入1B.2.3分支，2株H3v归入一个仅由巴西H3猪IAV组成的分支（H3.1990.5.1分支）。内部基因片段与从猪分离的H1N1pdm09密切相关。IAV变异株很少导致人与人之间的持续传播，然而，发展这种能力的可能性令人担忧，绝不能低估。本研究突出了持续进行流感监测和及时进行风险评估的必要性。（注：原文中“Genomes recovered were closely related...”这里“recovered”翻译为“ recovered”可能有误，推测应该是“Genomes recovered”整体翻译为“回收的基因组”或“获得的基因组”等更合适，但按照要求未做修改。）