Department of Pharmacology, Hyogo College of Medicine, Hyogo 663-8501, Japan.
Brain Res. 2012 Jan 6;1429:155-63. doi: 10.1016/j.brainres.2011.10.037. Epub 2011 Oct 26.
Repeated intermittent administration of amphetamines acutely increases appetitive and consummatory aspects of motivated behaviors as well as general activity and exploratory behavior, including voluntary running wheel activity. Subsequently, if the drug is withdrawn, the frequency of these behaviors decreases, which is thought to be indicative of dysphoric symptoms associated with amphetamine withdrawal. Such decreases may be observed after chronic treatment or even after single drug administrations. In the present study, the effect of acute methamphetamine (METH) on running wheel activity, horizontal locomotion, appetitive behavior (food access), and consummatory behavior (food and water intake) was investigated in mice. A multi-configuration behavior apparatus designed to monitor the five behaviors was developed, where combined measures were recorded simultaneously. In the first experiment, naïve male ICR mice showed gradually increasing running wheel activity over three consecutive days after exposure to a running wheel, while mice without a running wheel showed gradually decreasing horizontal locomotion, consistent with running wheel activity being a positively motivated form of natural motor activity. In experiment 2, increased horizontal locomotion and food access, and decreased food intake, were observed for the initial 3h after acute METH challenge. Subsequently, during the dark phase period decreased running wheel activity and horizontal locomotion were observed. The reductions in running wheel activity and horizontal locomotion may be indicative of reduced dopaminergic function, although it remains to be seen if these changes may be more pronounced after more prolonged METH treatments.
反复间歇性给予安非他命会急性增加动机行为的欲望和完成方面，以及一般活动和探索行为，包括自愿跑步轮活动。随后，如果停药，这些行为的频率会降低，这被认为是与安非他命戒断相关的不愉快症状的指标。这种减少可能在慢性治疗后甚至在单次药物给药后观察到。在本研究中，研究了急性甲基苯丙胺（METH）对老鼠跑步轮活动、水平运动、食欲行为（食物获取）和完成性行为（食物和水摄入）的影响。开发了一种多配置行为装置来监测五种行为，其中同时记录综合措施。在第一个实验中，暴露于跑步轮后的连续三天，新生雄性 ICR 小鼠的跑步轮活动逐渐增加，而没有跑步轮的小鼠的水平运动逐渐减少，这与跑步轮活动是一种积极的自然运动活动形式一致。在实验 2 中，在急性 METH 挑战后的最初 3 小时内观察到水平运动和食物获取增加，以及食物摄入量减少。随后，在黑暗期观察到跑步轮活动和水平运动减少。跑步轮活动和水平运动的减少可能表明多巴胺能功能降低，尽管尚不清楚这些变化在更长期的 METH 治疗后是否会更加明显。
