Human Brain Research Center, Kyoto University Graduate school of Medicine, Sakyo-ku, Kyoto 606-8507, Japan.
Neuroimage. 2012 Feb 15;59(4):3373-8. doi: 10.1016/j.neuroimage.2011.10.092. Epub 2011 Nov 4.
Previous neuroimaging studies using manual Stop signal task showed the inhibitory-related areas in the pre-supplementary motor area (pre-SMA) and ventrolateral prefrontal cortex (VLPFC). However, most previous studies employed the manual response inhibition task and the brain representation of the response inhibition of the other body parts has been rarely studied. To further understand the precise brain processing of response inhibition, we performed the event-related fMRI study of Stop signal tasks using the hand and foot response to reveal the common prefrontal region relevant for response inhibition in 13 subjects. We found that the pre-SMA and bilateral VLPFC were commonly activated in successful response inhibition both for hand and foot tasks. The comparison of brain activation between hand and foot response inhibition tasks did not show any significant difference in the prefrontal area. In addition, there was no significant difference for peak coordinates in the pre-SMA and bilateral VLPFC between hand and foot tasks. These findings indicate the common neural network for inhibition of initiated responses regardless of the hand and foot.
先前使用手动停止信号任务的神经影像学研究表明，预备运动区（pre-SMA）和腹外侧前额叶皮层（VLPFC）中存在与抑制相关的区域。然而，大多数先前的研究采用手动反应抑制任务，而其他身体部位的反应抑制的大脑表现很少被研究。为了进一步了解反应抑制的精确大脑处理，我们使用手和脚反应进行了事件相关 fMRI 停止信号任务研究，以揭示 13 名受试者中与反应抑制相关的共同前额叶区域。我们发现，在手和脚任务中，成功的反应抑制都会共同激活 pre-SMA 和双侧 VLPFC。在手和脚反应抑制任务之间的大脑激活比较中，在前额叶区域没有显示出任何显著差异。此外，在手和脚任务之间，pre-SMA 和双侧 VLPFC 的峰值坐标也没有显著差异。这些发现表明，无论使用手还是脚，发起反应的抑制都存在共同的神经网络。
