Chalmers Sexual and Reproductive Health Service, NHS Lothian, Edinburgh, Scotland, UK.
Contraception. 2012 May;85(5):458-64. doi: 10.1016/j.contraception.2011.10.002. Epub 2011 Nov 12.
Subcutaneous depo-medroxyprogesterone acetate (DMPA-SC) offers the possibility of self-administration.
This is a pilot study of self-administration of DMPA-SC. Existing users of the intramuscular preparation (DMPA-IM) who wished to self-inject (n=64) were taught self-administration using DMPA-SC. The main outcome was the continuation rate of the method at 12 months compared to a control group of existing users of DMPA-IM (n=64) who continued to attend a clinic to receive the method. Women's satisfaction with the method and the proportion of self-injections given at correct time were also determined.
The 12-month discontinuation rate of the DMPA-SC group (12%) did not differ significantly from that of the DMPA-IM group (22%) (95% confidence intervals of 13%-33% and 6%-23% for DMPA-SC and DMPA-IM, respectively; p=.23). All self-injections were given within the appropriate interval. There was no significant difference in the proportion of women in either group who were satisfied with the method.
Self-administration of DMPA-SC for contraception is feasible and is associated with similar continuation rates and satisfaction to clinician-administered DMPA-IM.
皮下注射的醋酸甲羟孕酮（DMPA-SC）可以实现自我管理。
这是一项 DMPA-SC 自我管理的试点研究。希望自我注射的肌肉内制剂（DMPA-IM）现有使用者（n=64）接受了 DMPA-SC 自我管理的培训。主要结果是与继续在诊所接受该方法的 DMPA-IM 现有使用者（n=64）对照组相比，该方法在 12 个月时的继续率。还确定了女性对该方法的满意度和正确时间给予自我注射的比例。
DMPA-SC 组的 12 个月停药率（12%）与 DMPA-IM 组（22%）无显著差异（DMPA-SC 和 DMPA-IM 的 95%置信区间分别为 13%-33%和 6%-23%；p=.23）。所有自我注射均在适当的间隔内进行。两组中对该方法感到满意的女性比例无显著差异。
DMPA-SC 的避孕自我管理是可行的，与临床医生管理的 DMPA-IM 相比，具有相似的继续率和满意度。
