Centre de Recherche Fernand-Séguin, Hôpital Louis-Hippolyte Lafontaine, Montreal, Canada; Department of Psychiatry, Faculty of Medicine, University of Montreal, Montreal, Canada.
Centre de Recherche Fernand-Séguin, Hôpital Louis-Hippolyte Lafontaine, Montreal, Canada; Department of Psychiatry, Faculty of Medicine, University of Montreal, Montreal, Canada.
Psychiatry Res. 2011 Dec 30;194(3):245-256. doi: 10.1016/j.pscychresns.2011.05.010. Epub 2011 Nov 12.
Schizophrenia patients are often impaired in their memory for emotional events compared with healthy subjects. Investigations of the neural correlates of emotional memory in schizophrenia patients are scarce in the literature. The present study aimed to compare cerebral activations in schizophrenia patients and healthy controls during memory retrieval of emotional images that varied in both valence and arousal. In a study with functional magnetic resonance imaging, 37 schizophrenia patients were compared with 37 healthy participants while performing a yes/no recognition paradigm with positive, negative (differing in arousal intensity) and neutral images. Schizophrenia patients performed worse than healthy controls in all experimental conditions. They showed less cerebral activation in limbic and prefrontal regions than controls during retrieval of negatively valenced stimuli, but had a similar pattern of brain activation compared with controls during retrieval of positively valenced stimuli (particularly in the high arousal condition) in the cerebellum, temporal lobe and prefrontal cortex. Both groups demonstrated increased brain activations in the high relative to low arousing conditions. Our results suggest atypical brain function during retrieval of negative pictures, but intact functional circuitry of positive affect during episodic memory retrieval in schizophrenia patients. The arousal data revealed that schizophrenia patients closely resemble the control group at both the behavioral and neurofunctional level.
精神分裂症患者的情绪事件记忆往往比健康受试者受损。在精神分裂症患者中，情绪记忆的神经相关性研究在文献中很少见。本研究旨在比较精神分裂症患者和健康对照组在回忆情绪图像时的大脑激活情况，这些图像在效价和唤醒度上都有所不同。在一项功能磁共振成像研究中，37 名精神分裂症患者与 37 名健康参与者进行了比较，他们在进行肯定、否定（唤醒强度不同）和中性图像的是/否识别范式时。在所有实验条件下，精神分裂症患者的表现都比健康对照组差。与对照组相比，他们在回忆负性效价刺激时，边缘和前额叶区域的大脑激活较少，但在回忆正性效价刺激时（特别是在高唤醒条件下），大脑激活模式与对照组相似（特别是在高唤醒条件下），在小脑、颞叶和前额叶皮质。两组在高唤醒条件下的大脑激活均增加。我们的研究结果表明，在回忆负性图片时，大脑功能异常，但精神分裂症患者的正性情感记忆的功能回路完好。唤醒数据表明，精神分裂症患者在行为和神经功能水平上都与对照组非常相似。
