Bernard Jessica A, Russell Courtney E, Newberry Raeana E, Goen James R M, Mittal Vijay A
Department of Psychology, Texas A&M University, United States; Texas A&M Institute for Neuroscience, Texas A&M University, United States.
Department of Psychology & Neuroscience, University of Colorado Boulder, United States.
Neuroimage Clin. 2017 Feb 11;14:450-463. doi: 10.1016/j.nicl.2017.01.034. eCollection 2017.
The diverse circuits and functional contributions of the basal ganglia, coupled with known differences in dopaminergic function in patients with schizophrenia, suggest they may be an important contributor to the etiology of the hallmark symptoms and cognitive dysfunction experienced by these patients. Using activation-likelihood-estimation meta-analysis of functional imaging research, we investigated differences in activation patterns in the basal ganglia in patients with schizophrenia, relative to healthy controls across task domains. This analysis included 42 functional neuroimaging studies, representing a variety of behavioral domains that have been linked to basal ganglia function in prior work. We provide important new information about the functional activation patterns and functional topography of the basal ganglia for different task domains in healthy controls. Crucially however, we demonstrate that across task domains, patients with schizophrenia show markedly decreased activation in the basal ganglia relative to healthy controls. Our results provide further support for basal ganglia dysfunction in patients with schizophrenia, and the broad dysfunction across task domains may contribute to the symptoms and cognitive deficits associated with schizophrenia.
基底神经节多样的神经回路及功能作用，再加上已知精神分裂症患者多巴胺能功能存在差异，这表明基底神经节可能是导致这些患者标志性症状及认知功能障碍病因的一个重要因素。通过对功能成像研究进行激活可能性估计元分析，我们调查了精神分裂症患者与健康对照者在不同任务领域中基底神经节激活模式的差异。该分析纳入了42项功能性神经影像学研究，涵盖了先前研究中与基底神经节功能相关的各种行为领域。我们提供了关于健康对照者不同任务领域中基底神经节功能激活模式和功能地形图的重要新信息。然而，至关重要的是，我们证明在所有任务领域中，精神分裂症患者相对于健康对照者，基底神经节的激活明显减少。我们的结果进一步支持了精神分裂症患者存在基底神经节功能障碍，且跨任务领域的广泛功能障碍可能导致了与精神分裂症相关的症状和认知缺陷。
