自闭症儿童在接受益生菌治疗后的阿糖醇水平。

The level of arabinitol in autistic children after probiotic therapy.

机构信息

Institute of General and Ecological Chemistry, Department of Chemistry, Technical University of Lodz, Lodz, Poland.

出版信息

Nutrition. 2012 Feb;28(2):124-6. doi: 10.1016/j.nut.2011.08.002. Epub 2011 Nov 12.

DOI:10.1016/j.nut.2011.08.002

PMID:22079796

Abstract

OBJECTIVE

The level of D-arabinitol (DA) and the ratio of D-/L-arabinitol (DA/LA) in the urine of children with autism were investigated. The changes in DA/LA after probiotic treatment in urine samples of children with autism were studied.

METHODS

DA and LA and the DA/LA ratio were identified by capillary gas chromatography/mass spectrometry in urine before and after the probiotic therapy.

RESULTS

The level of DA is significantly higher (P < 0.05) in the urine of autistic children before (A) and after probiotic supplementation (A1) (160.04 ± 22.88 μmol/mmol creatinine and 89.53 ± 37.41 μmol/mmol creatinine, respectively). Nonetheless, the probiotic supplementation let to a significant decrease in DA and DA/LA and to a significant improvement in ability of concentration and carrying out orders.

CONCLUSION

The use of probiotics seems to be helpful in reducing the level of DA and the ratio of DA/LA in the urine of children with autism.

摘要

目的

研究自闭症儿童尿液中的 D-阿拉伯糖醇（DA）水平和 D-/L-阿拉伯糖醇（DA/LA）比值。研究自闭症儿童尿液中益生菌治疗后 DA/LA 的变化。

方法

采用毛细管气相色谱/质谱法对益生菌治疗前后尿液中的 DA 和 LA 及其 DA/LA 比值进行鉴定。

结果

自闭症儿童尿液中的 DA 水平在益生菌补充前（A）和补充后（A1）均显著升高（P < 0.05）（分别为 160.04 ± 22.88 μmol/mmol 肌酐和 89.53 ± 37.41 μmol/mmol 肌酐）。然而，益生菌补充后，DA 和 DA/LA 显著降低，集中注意力和执行指令的能力显著提高。