Perova N V, Gerasimova E N, Chernysheva N P, Nikitina N A, Shcherbakova I A
Vopr Med Khim. 1979 Mar-Apr;25(2):185-92.
Some properties of very low density lipoproteins were studied under conditions causing an increase of their concentration in blood plasma. Content of high molecular apolipoprotein B and low molecular lipoproteins were estimated after fractionation using column chromatography and selective precipitation with tetramethylurea. In 216 men (40-59 years old) with hypertriglyceridemia the increase in content of particles of very low density lipoproteins was accompanied by simultaneous alteration in their composition in blood plasma: content of low molecular polypeptides, triglycerides and cholesterol was increased per a weight unit of apoprotein B. At the same time, the absolute concent of apoprotein B and of low molecular apoproteins of very low density lipoproteins was increased in blood plasma. The most distinct alteration in the ratio of apolipoproteins to very low density lipoproteins was observed, if content of testosterone--activator of lipoprotein lipase--was decreased in blood plasma.
在导致极低密度脂蛋白在血浆中浓度升高的条件下，对其一些特性进行了研究。使用柱色谱法进行分级分离并通过四甲基脲选择性沉淀后，估算了高分子载脂蛋白B和低分子脂蛋白的含量。在216名患有高甘油三酯血症的男性（40 - 59岁）中，极低密度脂蛋白颗粒含量的增加伴随着其血浆成分的同时改变：每单位重量的载脂蛋白B中，低分子多肽、甘油三酯和胆固醇的含量增加。同时，血浆中载脂蛋白B和极低密度脂蛋白的低分子载脂蛋白的绝对浓度增加。如果血浆中脂蛋白脂肪酶的激活剂睾酮含量降低，则观察到载脂蛋白与极低密度脂蛋白比例的最明显变化。
