Padrón R S, Más J, Zamora R, Riverol F, Licea M, Mallea L, Rodríguez J
Department of Human Reproduction, National Institute of Endocrinology, Habana, Cuba.
Int Urol Nephrol. 1989;21(5):515-9. doi: 10.1007/BF02549590.
We studied 19 male patients with primary hyperlipoproteinaemia, a control group of 28 healthy men and 44 infertile males before any treatment was undertaken. Spermiogram, seminal biochemical studies, measurements of plasma hormone levels and lipid determinations were carried out. Most hyperlipoproteinaemic patients showed abnormalities in the spermiograms and the mean values were lower than in the controls except for semen volume. Seminal biochemical determinations were normal in the majority and the hormone profile showed some abnormal values, mainly for E2. Lipid abnormalities were more common in azoospermic infertile men and mean lipid levels were higher. Correlation studies suggest that high levels of C and/or Tg are associated with poor semen quality and higher FSH levels. The results of our studies suggest that high lipid levels exert adverse direct effects at the testicular level.
我们研究了19例原发性高脂蛋白血症男性患者、28名健康男性组成的对照组以及44名未接受任何治疗的不育男性。进行了精液分析、精液生化研究、血浆激素水平测定和血脂测定。大多数高脂蛋白血症患者精液分析显示异常，除精液量外，各项平均值均低于对照组。大多数患者精液生化测定正常，激素水平显示一些异常值，主要是雌二醇（E2）。脂质异常在无精子症不育男性中更为常见，平均脂质水平更高。相关性研究表明，高水平的胆固醇（C）和/或甘油三酯（Tg）与精液质量差和促卵泡生成素（FSH）水平升高有关。我们的研究结果表明，高血脂水平在睾丸水平产生不良直接影响。
