Pharmacy Faculty, Ahmad Dahlan University, Yogyakarta, Indonesia.
Int J Gynecol Cancer. 2012 Jan;22(1):139-45. doi: 10.1097/IGC.0b013e318234f9ee.
Quality of life (QoL) has become a major outcome in the treatment of patients with cancer. This study is aimed at examining the impact of chemotherapy-induced nausea and vomiting on QoL of patients with gynecologic cancer in Indonesia.
Chemotherapy-naive patients with gynecologic cancer, who were treated with cisplatin at a dosage 50 mg/m or higher as monotherapy or as part of combination chemotherapy regimens, were recruited in the Oncology Department, Dr. Sardjito Hospital, Yogyakarta, Indonesia. Quality of life was assessed by using the Indonesian version of the European Organization for Research and Treatment for Cancer of Quality of Life Questionnaire and Short Form-36, administered immediately before and on day 5 after chemotherapy administration. Patients used a daily diary to record nausea and vomiting during 5 days after chemotherapy.
Most (74.9%) of the 179 patients experienced delayed emesis during the 5 days after chemotherapy despite prophylactic use of antiemetics. The delayed nausea and emesis caused significant negative impact on patients' QoL. Nausea in the delayed phase caused negative effects on patients' QoL.
Patients reported a negative impact on the QoL of delayed emesis after chemotherapy. Poor prophylaxis of patients' nausea and vomiting after chemotherapy interferes with patients' QoL. Medical and behavioral interventions may help to alleviate the negative consequences of chemotherapeutic treatment in patients with gynecologic cancers treated with suboptimal antiemetics.
生活质量（QoL）已成为癌症患者治疗的主要结果。本研究旨在探讨化疗引起的恶心和呕吐对印度尼西亚妇科癌症患者生活质量的影响。
在印度尼西亚日惹的 Sardjito 医院肿瘤科招募了接受顺铂（剂量为 50mg/m 或更高）单药治疗或联合化疗方案治疗的妇科癌症化疗初治患者。使用欧洲癌症研究与治疗组织生活质量问卷和健康调查简表（SF-36）的印度尼西亚版，在化疗前和化疗后第 5 天评估生活质量。患者使用每日日记记录化疗后 5 天内的恶心和呕吐情况。
尽管使用了止吐药进行预防，但在化疗后 5 天内，179 例患者中有 74.9%（134 例）经历了延迟性呕吐。延迟性恶心和呕吐对患者的生活质量产生了显著的负面影响。延迟期的恶心对患者的生活质量产生了负面影响。
患者报告化疗后延迟性呕吐对生活质量产生负面影响。化疗后患者恶心和呕吐的预防效果不佳会干扰患者的生活质量。医疗和行为干预措施可能有助于减轻接受低剂量止吐药治疗的妇科癌症患者化疗治疗的负面后果。
