Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta 55164, Indonesia.
Faculty of Psychology, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Int J Clin Pract. 2023 Mar 3;2023:9357299. doi: 10.1155/2023/9357299. eCollection 2023.
One of the important outcomes to define the success of cancer treatment is the health-related quality of life (HRQoL) that can be measured using generic and/or specific instruments. Our study aims to define the cancer patients' HRQoL in some hospitals in Indonesia as measured by the European Organization for Research and Treatment for Cancer (EORTC QLQ-C30) and the EQ-5D-5L, to define the differences of cancer patients' HRQoL referring to patients' characteristics, and to explore determinants of cancer patients' HRQoL. We recruited 451 cancer patients using a cross-sectional design in two referral hospitals in Central Java, Indonesia, using the purposive sampling technique. All subjects, recruited from July 2020 to October 2021, met the inclusion criteria, namely, adult patients diagnosed with cancers in all stages who willingly participated in the study. The Indonesian value set was used to obtain the EQ-5D-5L index score. We further analyzed the data based on cancer stages and compared two questionnaires using independent t test. We highlighted that most of the cancer patients are female (69.4%), young (86%), and at advanced stages of cancer (54.1%). The physical and role functions and global health status of the cancer patients are poor, and the most severe symptom is fatigue. Moreover, most of them experience severe pain and perform daily activities with difficulties. Some patients' characteristics show significant influences on the HRQoL domains in both questionnaires ( < 0.05). Interestingly, both of the questionnaires have shown significant correlations between similar domains and revealed the poor HRQoL of advanced cancer patients ( < 0.05). Our study finds that cancer patients still have poor HRQoL in some domains. We suggest to the health providers that they apply education and psychological intervention to increase their HRQoL.
癌症治疗成功的重要结果之一是健康相关的生活质量（HRQoL），可以使用通用和/或特定的工具进行测量。我们的研究旨在通过欧洲癌症研究与治疗组织（EORTC）生活质量问卷核心 30 项（QLQ-C30）和 EQ-5D-5L 来定义印度尼西亚一些医院的癌症患者的 HRQoL，确定癌症患者 HRQoL 与其特征的差异，并探讨癌症患者 HRQoL 的决定因素。我们采用横断面设计，在印度尼西亚中爪哇的两家转诊医院使用目的抽样技术招募了 451 名癌症患者。所有于 2020 年 7 月至 2021 年 10 月期间符合纳入标准（即诊断为各阶段癌症的成年患者，自愿参与研究）的患者均被纳入研究。我们使用印度尼西亚价值量表获得 EQ-5D-5L 指数评分。我们进一步根据癌症分期分析数据，并使用独立 t 检验比较两份问卷。我们强调，大多数癌症患者为女性（69.4%）、年轻（86%）和癌症晚期（54.1%）。癌症患者的身体和角色功能以及整体健康状况较差，最严重的症状是疲劳。此外，他们中的大多数人经历严重的疼痛，日常活动困难。一些患者特征对两份问卷的 HRQoL 各领域均有显著影响（<0.05）。有趣的是，两份问卷在相似领域均显示出显著相关性，表明晚期癌症患者的 HRQoL 较差（<0.05）。我们的研究发现，癌症患者在某些领域仍存在较差的 HRQoL。我们建议医疗服务提供者实施教育和心理干预，以提高他们的 HRQoL。
