Rowse G J, Rowan R E, Weinberg J, Emerman J T
Department of Anatomy, University of British Columbia, Vancouver, Canada.
Cancer Lett. 1990 Oct 8;54(1-2):81-7. doi: 10.1016/0304-3835(90)90095-f.
We have previously demonstrated that differential housing conditions alter the growth rate of the Shionogi mouse mammary carcinoma (SC115). The present study was undertaken to determine if natural killer (NK) cells are involved in mediating the effects of differential housing on SC115 tumour growth rate. Splenic NK cell activity was assayed at 24 h, 3 days and 1 week post-injection in both tumour- and vehicle-injected animals. Significant stimulation of splenic NK cell activity occurred 3 days post-injection of SC115 cells. However, no correlation was observed between the level of splenic NK cell activity and tumour growth rate induced by housing condition. We conclude that either splenic NK cell activity does not accurately reflect NK cell activity at the tumour site or that NK cells are not a significant regulator of the differential tumour growth rates seen in this model.
我们之前已经证明，不同的饲养条件会改变Shiogi小鼠乳腺癌（SC115）的生长速度。本研究旨在确定自然杀伤（NK）细胞是否参与介导不同饲养条件对SC115肿瘤生长速度的影响。在注射肿瘤细胞和注射赋形剂的动物中，分别在注射后24小时、3天和1周测定脾脏NK细胞活性。注射SC115细胞后3天，脾脏NK细胞活性受到显著刺激。然而，未观察到脾脏NK细胞活性水平与饲养条件诱导的肿瘤生长速度之间存在相关性。我们得出结论，要么脾脏NK细胞活性不能准确反映肿瘤部位的NK细胞活性，要么NK细胞不是该模型中所见不同肿瘤生长速度的重要调节因子。
