Hoffman-Goetz L, Simpson J R, Arumugam Y
Department of Health Studies, Faculty of Applied Health Sciences, University of Waterloo, Ontario, Canada.
Physiol Behav. 1991 Mar;49(3):657-60. doi: 10.1016/0031-9384(91)90297-2.
Various psychosocial stressors, such as housing condition and rotation, have been reported to influence tumour growth. This study assessed the influence of housing condition and change in housing condition on natural killer (NK) cell activity, an important component of natural immune defense against cancer. Mice which were individually housed for four weeks did not differ from group-housed mice in NK cell cytolytic activity against tumour targets in vitro or in the frequency of NK cells in the spleen. Switching of housing condition (group to individual, individual to group) for one week did not change the splenic NK cytolytic capacity relative to mice which were not switched. The two groups of mice which experienced a change in housing condition were, however, significantly different from each other. These data suggest that an acute change in housing condition, rather than the housing condition per se, has differential effects on the capacity to kill tumours by NK cells.
据报道，各种社会心理压力源，如居住条件和轮换，会影响肿瘤生长。本研究评估了居住条件及居住条件变化对自然杀伤（NK）细胞活性的影响，NK细胞活性是天然免疫抗癌防御的重要组成部分。单独饲养四周的小鼠与群居小鼠相比，在体外对肿瘤靶标的NK细胞溶细胞活性或脾脏中NK细胞的频率方面并无差异。将居住条件转换（从群居转换为单独饲养，或从单独饲养转换为群居）一周，相对于未转换居住条件的小鼠，脾脏NK溶细胞能力并未改变。然而，经历居住条件变化的两组小鼠彼此之间存在显著差异。这些数据表明，居住条件的急性变化而非居住条件本身，对NK细胞杀伤肿瘤的能力有不同影响。
