Roebuck B D, McCaffrey J, Baumgartner K J
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03756.
Cancer Res. 1990 Nov 1;50(21):6811-6.
Studies were undertaken to evaluate the effects of exercise on the development of pancreatic cancer. Exercise is one life-style factor that has received little attention with regard to its role in the etiology of cancer. Male Lewis and female F344 rats were initiated with azaserine during the suckling period and weaned to the experimental protocols. Food and water were available ad libitum. A purified diet of 20% unsaturated fat was fed to both the sedentary and exercise groups. Rats of the exercise group had free access to voluntary exercise wheels. At approximately 2 and 4 months postinitiation, pancreases were evaluated for the number and size of azaserine-induced putative preneoplastic foci by quantitative stereology. Voluntary exercise activity peaked at approximately 2 months postinitiation with a gradual decline in activity there-after. Male Lewis rats averaged 0.95 +/- 0.13 km/day (SE) and female F344 rats averaged 2.73 +/- 0.26 km/day of voluntary wheel running. Compared with the sedentary groups, male Lewis and female F344 rats with access to the running wheels had significantly smaller foci at 4 months postinitiation. Azaserine-induced foci were evaluated in the male Lewis rats at both 2 and 4 months postinitiation. At 4 months postinitiation, the size and growth rate (as measured by [3H]thymidine autoradiography) of foci were less in the rats with access to the exercise wheels. No differences were observed at 2 months postinitiation. Access to voluntary exercise reduced the growth rate of azaserine-induced pancreatic foci. The effect occurred late in the postinitiation phase and was not directly related to the extent of running activity early in the postinitiation phase.
开展了多项研究以评估运动对胰腺癌发展的影响。运动作为一种生活方式因素，其在癌症病因学中的作用很少受到关注。雄性Lewis大鼠和雌性F344大鼠在哺乳期用氮杂丝氨酸进行诱发处理，然后断奶并按照实验方案饲养。食物和水可随意获取。向久坐组和运动组大鼠投喂含20%不饱和脂肪的纯化饮食。运动组大鼠可自由使用自行运动轮。在诱发处理后约2个月和4个月时，通过定量体视学评估胰腺中氮杂丝氨酸诱导的假定癌前病灶的数量和大小。自行运动活动在诱发处理后约2个月达到峰值，此后活动逐渐减少。雄性Lewis大鼠平均每天自行运动0.95±0.13千米（标准误），雌性F344大鼠平均每天自行运动2.73±0.26千米。与久坐组相比，可使用运动轮的雄性Lewis大鼠和雌性F344大鼠在诱发处理后4个月时病灶明显更小。在诱发处理后2个月和4个月时对雄性Lewis大鼠的氮杂丝氨酸诱导病灶进行了评估。在诱发处理后4个月时，可使用运动轮的大鼠病灶大小和生长速率（通过[3H]胸腺嘧啶核苷放射自显影测量）较小。在诱发处理后2个月时未观察到差异。自行运动可降低氮杂丝氨酸诱导的胰腺病灶的生长速率。这种作用在诱发处理后期出现，与诱发处理早期的运动活动程度无直接关系。
