失眠的神经生物学模型。
A Neurobiological Model of Insomnia.
作者信息
Buysse Daniel J, Germain Anne, Hall Martica, Monk Timothy H, Nofzinger Eric A
机构信息
University of Pittsburgh Sleep Medicine Institute and Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
出版信息
Drug Discov Today Dis Models. 2011 Winter;8(4):129-137. doi: 10.1016/j.ddmod.2011.07.002.
Abstract
Insomnia is a common clinical condition resulting in significant costs and morbidity. Previous models of insomnia focusing on psychological and behavioral processes are useful clinically, but lack neurobiological specificity. We propose an insomnia model based on basic and clinical neuroscience findings, and hypothesize that insomnia results from persistent activity in wake-promoting neural structures during NREM sleep. The simultaneous occurrence of sleeping and waking neural activity helps to explain clinical phenomenology and treatment effects in insomnia.
摘要
失眠是一种常见的临床病症，会导致巨大的成本和发病率。以往专注于心理和行为过程的失眠模型在临床上很有用，但缺乏神经生物学特异性。我们基于基础和临床神经科学研究结果提出了一种失眠模型，并假设失眠是由非快速眼动睡眠期间促醒神经结构的持续活动所致。睡眠和清醒神经活动的同时出现有助于解释失眠的临床现象学和治疗效果。
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