杂芳基硼酸和乙烯基氯的铃木-宫浦偶联反应。
Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides.
机构信息
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT 84112, USA.
出版信息
Chem Commun (Camb). 2012 Jan 7;48(2):203-5. doi: 10.1039/c1cc15990a. Epub 2011 Nov 14.
PMID:22083103
Abstract
A protocol for the Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides that minimizes protodeboronation is described. A combination of catalytic amounts of Pd(OAc)(2) and SPhos in conjunction with CsF in isopropanol effectively affords a variety of coupled products. Surprisingly, a dramatic temperature dependence in product selectivity was observed.
摘要
描述了一种最大限度减少脱硼基化的杂芳基硼酸和乙烯基氯的铃木-宫浦偶联反应的方案。在异丙醇中使用催化量的 Pd(OAc)(2)和 SPhos 以及 CsF 的组合有效地得到了各种偶联产物。令人惊讶的是，观察到产物选择性的显著温度依赖性。
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