Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT 84112, USA.
Chem Commun (Camb). 2012 Jan 7;48(2):203-5. doi: 10.1039/c1cc15990a. Epub 2011 Nov 14.
A protocol for the Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides that minimizes protodeboronation is described. A combination of catalytic amounts of Pd(OAc)(2) and SPhos in conjunction with CsF in isopropanol effectively affords a variety of coupled products. Surprisingly, a dramatic temperature dependence in product selectivity was observed.
描述了一种最大限度减少脱硼基化的杂芳基硼酸和乙烯基氯的铃木-宫浦偶联反应的方案。在异丙醇中使用催化量的 Pd(OAc)(2)和 SPhos 以及 CsF 的组合有效地得到了各种偶联产物。令人惊讶的是，观察到产物选择性的显著温度依赖性。
