Pĕnicková V, Jemelík R, Opavský J, Jezdinský J
Ustav pro výzkum VNC, UP, Olomouc.
Cesk Neurol Neurochir. 1990 Jul;53(4):242-8.
The authors tested in 36 patients treatment of chronic intractable pain by percutaneous iontophoretic administration of an inhibitor of microtubular transport, Vinblastine inj. (G. Richter, Hungary). The groups comprised: (1) 16 patients with severe radicular pain after one or several operations of prolapsed lumbar intervertebral discs, (2) 20 patients with severe pain in the area of radicular dermal zones or dermal innervation areas of peripheral nerves. In every patient a minimum of 15 procedures were tried. Evaluation of the therapeutic effect was based on subjective data of the patient on the mitigation of pain in per cent, on the intensity of the current pain and the interference of the intensity of pain with daily activities. According to all criteria improvement was achieved in 31 subjects, i.e. in 86%. A favourable effect of treatment was observed after the 8th-10th administration. In the first group of patients clinically significant mitigation of algic symptoms was achieved in 69% of the treated subjects. In the second group a therapeutic effect was achieved in 90% of the patients. A marked difference between the two groups was found with respect to mitigation of the intensity of pain on completion of treatment. The mean mitigation of pain intensity in the first group was 24.1%, in the second group 47.7%. This difference is highly significant. With the exception of one female patient always a positive effect at the site of administration (beneath the anode) was observed.
作者对36例慢性顽固性疼痛患者进行了经皮离子电渗疗法，使用微管运输抑制剂长春碱注射液（匈牙利吉瑞大药厂生产）进行治疗。分组情况如下：（1）16例在进行了一次或多次腰椎间盘突出症手术后出现严重神经根性疼痛的患者；（2）20例在神经根性皮肤区域或周围神经皮肤支配区域出现严重疼痛的患者。对每位患者至少尝试进行15次治疗。治疗效果的评估基于患者关于疼痛减轻百分比、当前疼痛强度以及疼痛强度对日常活动干扰的主观数据。根据所有标准，31名受试者（即86%）病情得到改善。在第8至10次给药后观察到治疗有良好效果。在第一组患者中，69%接受治疗的受试者临床症状有明显减轻。在第二组中，90%的患者获得了治疗效果。在治疗结束时，两组在疼痛强度减轻方面存在显著差异。第一组疼痛强度的平均减轻率为24.1%，第二组为47.7%。这种差异非常显著。除一名女性患者外，在给药部位（阳极下方）均观察到了积极效果。
