Opavský J, Pĕnicková V, Jezdinský J
Cas Lek Cesk. 1989 May 5;128(19):590-4.
Iontophoretic administration of substances which influence the function of microtubuli in the peripheral nerves is one of the new ways how to suppress some types of refractory chronic pain. Based on a number of experimental data and encouraging clinical results, the authors used in the submitted work repeated iontophoretic administration of 0.01% Vinblastine (G. Richter, Hungary) into the painful zone in a group of 20 patients with several types of non-malignant pain. Objectivization of the evaluation was partly also due to the authors' own version of McGill Pain Questionnaire, along with the graphic presentation of algetic zones. Clinically detectable mitigation of pain was achieved in 14 subjects, in eight improvement persisted for more than six months and one year resp. No serious undesirable side-effects were observed in the investigated subjects.
通过离子电渗疗法给予影响周围神经微管功能的物质，是抑制某些类型难治性慢性疼痛的新方法之一。基于大量实验数据和令人鼓舞的临床结果，作者在提交的研究中，对20例患有多种非恶性疼痛的患者，在疼痛区域反复进行离子电渗给予0.01%长春碱（匈牙利吉瑞大药厂生产）。评估的客观化部分也得益于作者自己版本的麦吉尔疼痛问卷，以及疼痛区域的图形呈现。14名受试者的疼痛在临床上得到了可检测到的缓解，其中8名患者的改善持续了超过6个月和1年。在所研究的受试者中未观察到严重的不良副作用。
