MedLab Dental Oral Pathology Diagnostic Service and the Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Head Neck. 2013 Apr;35(4):599-604. doi: 10.1002/hed.21942. Epub 2011 Nov 15.
Malignant mesothelioma is a rare neoplasm that usually develops after exposure to asbestos and particularly involves the pleural cavity. It has a poor prognosis with aggressive local invasion and metastatic spread.
The literature relating to malignant mesothelioma metastatic to the oral region was reviewed.
In all, 14 cases of malignant mesothelioma metastatic to the oral cavity were found. All were from pleural mesotheliomas, the tongue was the most common site of metastasis (8/14), and most metastases (9/13) were of the epithelioid type. The newly reported case is only the second report of a mesothelioma metastasizing to the buccal mucosa. It showed strong immunopositivity for keratin markers, vimentin, calretinin, and Wilms tumor product-1.
The incidence of mesothelioma is predicted to continue to increase for at least another decade. Clinicians and pathologists should be aware of this lesion and its propensity to metastasize to the oral cavity.
恶性间皮瘤是一种罕见的肿瘤，通常在接触石棉后发展而来，尤其涉及胸膜腔。它具有侵袭性局部侵犯和转移性播散的不良预后。
回顾了有关恶性间皮瘤转移至口腔区域的文献。
共发现 14 例恶性间皮瘤转移至口腔。均来自胸膜间皮瘤，舌是最常见的转移部位（8/14），大多数转移（9/13）为上皮样型。新报告的病例仅是第二例报道的转移至颊黏膜的间皮瘤。它对角蛋白标志物、波形蛋白、钙视网膜蛋白和 Wilms 瘤产物-1 表现出强烈的免疫阳性。
间皮瘤的发病率预计至少在未来十年内还会继续增加。临床医生和病理学家应该意识到这种病变及其向口腔转移的倾向。
