Molecular Endocrinology Laboratory, KMEB, Department of Endocrinology and Metabolism, Medical Biotechnology Center, Odense University Hospital, University of Southern Denmark, SDU, DK-5000 Odense C, Denmark.
Eur J Endocrinol. 2012 Mar;166(3):359-71. doi: 10.1530/EJE-11-0646. Epub 2011 Nov 14.
Osteoblast differentiation and bone formation (osteogenesis) are regulated by transcriptional and post-transcriptional mechanisms. Recently, a novel class of regulatory factors termed micro-RNAs (miRNAs) has been identified as playing an important role in the regulation of many aspects of osteoblast biology including proliferation, differentiation, metabolism and apoptosis. Also, preliminary data from animal disease models suggest that targeting miRNAs in bone can be a novel approach to increase bone mass. This review highlights the current knowledge of miRNA biology and their role in bone formation and discusses their potential use in future therapeutic applications for metabolic bone diseases.
成骨细胞分化和骨形成（成骨作用）受转录和转录后机制的调节。最近，一类新的调节因子，称为 microRNAs（miRNAs），被确定在调节成骨细胞生物学的许多方面发挥着重要作用，包括增殖、分化、代谢和凋亡。此外，动物疾病模型的初步数据表明，靶向骨中的 miRNAs 可能是增加骨量的一种新方法。本文综述了 miRNA 生物学的最新知识及其在骨形成中的作用，并讨论了它们在代谢性骨疾病未来治疗应用中的潜在用途。
