Bacci Christian, Cassetta Giulia, Emanuele Bruno, Berengo Mario
Department of Medical and Surgical Specialities and Unit of Oral Surgery, Institute of Clinical Dentistry, University of Padua, Via Venezia, 90, 35100 Padua, Italy.
ISRN Surg. 2011;2011:917350. doi: 10.5402/2011/917350. Epub 2011 Apr 17.
The aim of this study was to assess the efficacy of Normast 300 mg in reducing swelling and pain after the surgical extraction of impacted lower third molars. Materials and Methods. A randomized, split-mouth, single-blind study was conducted on 30 patients between 18 and 30 years of age requiring lower third molar extraction. Patients underwent bilateral extractions in a randomized sequence, one extraction being performed under Normast treatment. The Normast treatment involved 2 tablets a day for 15 days. The parameters assessed at each procedure were trismus, swelling, pain, NSAID consumption, postoperative complications, drug tolerability, and safety. The results obtained were processed using repeated measures analysis of variance. Results. Perceived postoperative pain was reportedly significantly milder on Normast treatment than control. The trend of the means differed over time (P < .0001) and between the two extraction groups (P < .0221). On the other hand, for edema and trismus, the trend differed over time for both groups but did not differ between the two groups. Discussion. Our analyses indicate that patients experienced significantly less postoperative pain when they were treated with Normast. Conclusions. Administering Normast improves the postoperative course-in terms of pain-after lower third molar extraction.
本研究的目的是评估300毫克诺马斯（Normast）在减轻下颌阻生第三磨牙手术拔除后肿胀和疼痛方面的疗效。材料与方法。对30名年龄在18至30岁之间需要拔除下颌第三磨牙的患者进行了一项随机、双侧对照、单盲研究。患者按随机顺序进行双侧拔牙，一次拔牙在诺马斯治疗下进行。诺马斯治疗包括每天服用2片，持续15天。在每次手术中评估的参数包括张口受限、肿胀、疼痛、非甾体抗炎药的使用、术后并发症、药物耐受性和安全性。使用重复测量方差分析对获得的结果进行处理。结果。据报道，接受诺马斯治疗的患者术后疼痛明显比对照组轻。均值趋势在时间上存在差异（P < .0001），在两个拔牙组之间也存在差异（P < .0221）。另一方面，对于水肿和张口受限，两组的趋势在时间上存在差异，但两组之间没有差异。讨论。我们的分析表明，接受诺马斯治疗的患者术后疼痛明显减轻。结论。在下颌第三磨牙拔除后，服用诺马斯在疼痛方面改善了术后过程。
