Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China.
Org Lett. 2011 Dec 16;13(24):6516-9. doi: 10.1021/ol202807d. Epub 2011 Nov 15.
A palladium-catalyzed two or fourfold amination was established that allows regiospecific synthesis of a diversity-oriented library of 1,2-disubstituted (hetero)aryl fused imidazoles, and provides an exceptional tool for the discovery of fluorescent scaffolds with tunable fluorescence emission. These fluorophores have been applied as fluorescent probes for live cell imaging.
建立了钯催化的二或四元胺化反应，实现了 1,2-二取代（杂）芳基稠合咪唑的多样性导向库的区域选择性合成，为发现具有可调荧光发射的荧光骨架提供了一种独特的工具。这些荧光团已被用作活细胞成像的荧光探针。
