Departments of Medical Science, University of Calgary, Alberta, Canada.
Cancer Invest. 2011 Dec;29(10):676-82. doi: 10.3109/07357907.2011.626474.
Tumor vasculature is known to express high levels of the longest splice variant of tumor endothelial marker 8 (TEM8). Little is known about its expression by tumor cells. Five of eight cell breast cancer cell lines tested expressed significant levels of the longest TEM8 splice variant (TEM8.1), and to a lesser extent, the shortest splice variant (TEM8.3). Breast cancer cell lines expressing high levels of TEM8 are known to be more invasive and typify a more aggressive basal-like phenotype. In vivo studies in the 4T1 murine model showed enhanced tumor growth associated with increased tumor vascularity and metastasis to lymph nodes and lungs. These data suggest that TEM8.1 expression in breast cancer cells confers a more aggressive, proangiogenic phenotype.
肿瘤血管被认为表达高水平的肿瘤内皮标志物 8（TEM8）的最长剪接变体。关于肿瘤细胞的表达情况知之甚少。在测试的 8 种乳腺癌细胞系中，有 5 种表达了高水平的最长 TEM8 剪接变体（TEM8.1），其次是最短的剪接变体（TEM8.3）。已知表达高水平 TEM8 的乳腺癌细胞系具有更高的侵袭性，代表更具侵袭性的基底样表型。在 4T1 小鼠模型中的体内研究表明，与肿瘤血管生成和淋巴结及肺部转移增加相关的肿瘤生长增强。这些数据表明，乳腺癌细胞中 TEM8.1 的表达赋予了更具侵袭性、促血管生成的表型。
