Pietrzyk Łukasz, Korolczuk Agnieszka, Matysek Małgorzata, Arciszewski Marcin B, Torres Kamil
Department of Didactics and Medical Simulation, Faculty of Medicine, Medical University of Lublin, Lublin, Poland.
Department of General, Oncological and Minimally Invasive Surgery, 1st Military Clinical Hospital with the Outpatient Clinic in Lublin, Lublin, Poland.
Cancer Manag Res. 2021 Apr 9;13:3113-3122. doi: 10.2147/CMAR.S298165. eCollection 2021.
Despite the continuous improvements in prevention and detection of colorectal cancer (CRC), there is an urgent need to find a sensitive, specific, and noninvasive biomarker to improve the early diagnosis and prognosis of CRC. We aimed to evaluate the tissue TEM8 expression and the serum TEM8 concentration in CRC patients.
The study enrolled 42 CRC patients and 35 controls. Immunohistochemical staining was performed to assess the TEM8 tissue expression, whereas the serum TEM8 concentration was evaluated with the ELISA assay.
The expression of TEM8 observed in all primary colorectal tumor samples was significantly correlated with the TNM stages and the presence of lymphovascular invasion. The serum TEM8 concentration was significantly higher in CRC patients than in the controls. The TEM8 level was strongly associated with the TNM stage, depth of invasion, and lymph node and distant metastasis. Patients with a high serum TEM8 concentration had a worse overall survival (OS) rate than CRC patients with a low serum TEM8 level.
TEM8 may serve as a biomarker for the diagnosis of CRC and it has value in predicting the prognosis of patients with CRC.
尽管在结直肠癌（CRC）的预防和检测方面不断取得进展，但迫切需要找到一种敏感、特异且非侵入性的生物标志物，以改善CRC的早期诊断和预后。我们旨在评估CRC患者的组织TEM8表达和血清TEM8浓度。
该研究纳入了42例CRC患者和35例对照。采用免疫组织化学染色评估TEM8组织表达，而用ELISA法评估血清TEM8浓度。
在所有原发性结直肠肿瘤样本中观察到的TEM8表达与TNM分期和淋巴管侵犯显著相关。CRC患者的血清TEM8浓度显著高于对照组。TEM8水平与TNM分期、浸润深度、淋巴结及远处转移密切相关。血清TEM8浓度高的患者总生存率（OS）低于血清TEM8水平低的CRC患者。
TEM8可能作为CRC诊断的生物标志物，对预测CRC患者的预后具有价值。
