miRNA 序列在人类疾病中的功能相关性。
Functional relevance of miRNA sequences in human disease.
机构信息
Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
出版信息
Mutat Res. 2012 Mar 1;731(1-2):14-9. doi: 10.1016/j.mrfmmm.2011.10.014. Epub 2011 Nov 6.
Abstract
MicroRNA (miRNA) processing in the cytoplasm produces a miRNA duplex containing the forward, miRNA strand and the reverse, miRNA strand, which was thought to be degraded. However, recent evidence is challenging this dogma that miRNA is simply a non-functional byproduct of miRNA biogenesis. We present a comprehensive review of evidence that miRNA plays a significant role in cellular function and assembled a table outlining all of the publications before September 2011 that have reported on miRNA activity in human disease. Furthermore, we will present unexpected diagnostic and therapeutic implications due to the active miRNA status.
摘要
细胞质中的 microRNA (miRNA) 加工产生 miRNA 双链体，其中包含前向 miRNA 链和反向 miRNA 链，人们曾认为后者会被降解。然而，最近的证据对 miRNA 只是 miRNA 生物发生的无功能副产物这一教条提出了挑战。我们对 miRNA 在细胞功能中发挥重要作用的证据进行了全面综述，并整理了一份表格，列出了截至 2011 年 9 月之前所有报道 miRNA 在人类疾病中活性的出版物。此外，由于 miRNA 的活性状态，我们还将介绍一些意外的诊断和治疗意义。
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