尿视黄醇结合蛋白与肾小管损伤的相关性研究

[Correlation studies between urinary retinol binding protein and renal tubular damage].

作者信息

Xia Yuncheng, Peng Canhui, Qu Shen, Liu Fuyou, Peng Youming

机构信息

Huazhong University of Science and Technology,Wuhan, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Oct;36(10):1008-11. doi: 10.3969/j.issn.1672-7347.2011.10.013.

DOI:10.3969/j.issn.1672-7347.2011.10.013

PMID:22086002

Abstract

OBJECTIVE

To study correlation between urinary retinol binding protein (RBP) content and renal tubular damage.

METHODS

A total of 1 353 healthy people and 186 patients with renal tubular damage diagnosed by renal biopsy were enrolled. The indicators such as endogenous creatinine clearance rate (Ccr), creatinine(Cr), urinary retinol binding protein(RBP), urinary β(2)-microglobulin(β(2)-MG), urinary N-acety1-beta-D-glucosaminidase (NAG), urine specific gravity(SG), urine osmolality of the 2 groups were examined and compared. Score of tubulointerstitial impairing and all indicators were analyzed by Spearman rank correlation analysis, and the sensitivity and specificity of indicators were calculated.

RESULTS

Renal tubular damage was positively correlated with urinary RBP, β2-MG, NAG (r=0.863, P<0.001; r=0.777, P<0.001; r=0.374, P=0.002, respectively), while negatively correlated with urine osmolaling, SG (r=-0.519, P<0.001; r=-0.624, P<0.001, respectively). The specificity and sensitivity for renal tubular damage of RBP were 91.03% and 72.06%.

CONCLUSION

RBP is an idea marker for renal tubular damage, and is useful to diagnose renal tubular damage and assess the extent of the damage.

摘要

目的

研究尿视黄醇结合蛋白（RBP）含量与肾小管损伤之间的相关性。

方法

纳入1353名健康人和186例经肾活检确诊为肾小管损伤的患者。检测并比较两组的内生肌酐清除率（Ccr）、肌酐（Cr）、尿视黄醇结合蛋白（RBP）、尿β2微球蛋白（β2-MG）、尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）、尿比重（SG）、尿渗透压等指标。采用Spearman等级相关分析对肾小管间质损伤评分及各项指标进行分析，并计算各指标的敏感度和特异度。

结果

肾小管损伤与尿RBP、β2-MG、NAG呈正相关（r分别为0.863，P<0.001；r为0.777，P<0.001；r为0.374，P=0.002），而与尿渗透压、SG呈负相关（r分别为-0.519，P<0.001；r为-0.624，P<0.001）。RBP对肾小管损伤的特异度和敏感度分别为91.03%和72.06%。