Nuhoğlu Bariş, Balci Mustafa Bahadir Can, Aydin Memduh, Hazar Ismet, Onuk Özkan, Taş Tuncay, Fikri Onur
Clinics of II Urology, Taksim Training and Research Hospital, Istanbul, Turkey. drbnuhoglu @ gmail.com
Urol Int. 2011;87(4):400-4. doi: 10.1159/000329797. Epub 2011 Nov 11.
A prospective randomized study was conducted to evaluate the safety and effectiveness of bipolar plasma vaporization with a novel electrode that produces vaporization of the tissue (transurethral vaporization of the prostate, TUVP) immersed in isotonic saline compared to the standard transurethral resection of the prostate (TURP) in the treatment of benign prostatic hyperplasia (BPH).
From February 2009 to February 2010, 90 patients with BPH were randomized into two groups, and underwent conventional TURP (group 1) or TUVP (group 2) utilizing bipolar plasma vaporization with an innovative electrode (Olympus Winter & Ibe GmbH, Hamburg, Germany). International Prostate Symptom Scores (IPSS), transrectal ultrasonographic findings, maximal urine flow rates (Qmax), and postvoiding residual urine (PVRU) volumes of all cases were evaluated preoperatively and 1 month, 3 months, and 1 year postoperatively. Preoperative and postoperative serum hemoglobin, hematocrit and sodium concentrations of all patients were measured. All patients included in the study were monitored for 1 year.
In patients in group 1 (n = 47; mean age: 64.7 ± 7.3 years) TURP was performed. The patients in group 2 (n = 43; mean age: 65.4 ± 8.9 years) underwent bipolar TUVP. Cases in the two study groups matched for demographic characteristics and clinical parameters were assessed. The evaluation of IPSS scores, PVRU, Qmax, and prostatic volumes of the patients 1 month, 3 months, and 1 year postoperatively did not reveal any significant differences between the two groups. In group 2 (TUVP), postoperative catheter indwelling times were significantly shorter, and Na serum concentrations were also markedly lower (p < 0.005).
We detected similar effectiveness and morbidity rates in both groups. Bipolar TUVP has advantages such as shorter catheter indwelling times and hospital stays, and fewer bleeding episodes without any risk of transurethral resection syndrome. We believe that TUVP might be an alternative to TURP which is currently the 'gold standard' treatment in BPH.
开展一项前瞻性随机研究,以评估一种新型电极产生组织汽化作用(经尿道前列腺汽化术,TUVP)的双极等离子体汽化术在等渗盐水中与标准经尿道前列腺切除术(TURP)相比,治疗良性前列腺增生(BPH)的安全性和有效性。
2009年2月至2010年2月,90例BPH患者被随机分为两组,分别接受传统TURP(第1组)或使用创新电极(德国汉堡奥林巴斯温特&伊贝有限公司)进行双极等离子体汽化术的TUVP(第2组)。评估所有病例术前以及术后1个月、3个月和1年时的国际前列腺症状评分(IPSS)、经直肠超声检查结果、最大尿流率(Qmax)和排尿后残余尿量(PVRU)。测量所有患者术前和术后的血清血红蛋白、血细胞比容和钠浓度。纳入研究的所有患者均接受1年的监测。
第1组(n = 47;平均年龄:64.7±7.3岁)患者接受了TURP。第2组(n = 43;平均年龄:65.4±8.9岁)患者接受了双极TUVP。对两个研究组中人口统计学特征和临床参数相匹配的病例进行了评估。术后1个月、3个月和1年时对患者的IPSS评分、PVRU、Qmax和前列腺体积进行评估,结果显示两组之间没有任何显著差异。在第2组(TUVP)中,术后导尿管留置时间明显更短,血清钠浓度也明显更低(p < 0.005)。
我们在两组中检测到了相似的有效性和发病率。双极TUVP具有诸如导尿管留置时间和住院时间更短、出血事件更少且无经尿道切除综合征风险等优势。我们认为TUVP可能是目前BPH“金标准”治疗方法TURP的一种替代方案。