Sport Physiology Research Center and Department of Nutrition-Health School, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Int J Occup Med Environ Health. 2011 Dec;24(4):380-90. doi: 10.2478/s13382-011-0044-9. Epub 2011 Nov 16.
Cardiovascular - coronary heart disease, causing heart attack and heart failure is a leading cause of disability and death worldwide. The most important risk factors for CVD are well-established and physical activity has long been considered the cornerstone of interventions and has shown extremely important in reducing the burden of this disease. The aim of this study was to examine the association between activity and inactivity and non-lipid CVD risk factors in healthy military recruits.
Selected hormones and variables such as testosterone, free testosterone, Vitamin D, homocysteine, folic acid, with the inflammatory cytokines such as hsCRP, TNF-α and IL-6 were assessed in two groups (active = 50, inactive = 50), randomly matched by a questionnaire. Relationships between some measured variables and CVD risk factors were determined using simple correlation procedures.
Physically active subjects had significantly lower results of homocysteine (14.3±1.9 vs. 16.5±3.7, p < 0.000) and interleukin-6 (2.9.±5.3 vs. 6±8.2, p< 0.025) and tended to have a nearly significantly higher free testosterone level (13.1±7.1 vs. 11±5.3, p = 0.08). Significant correlations were found between BMI, WC, tHcy, and the corresponding risk factors; and also between hsCRP and IL-6, as well as TT and FT.
Reducing the risk factors of developing CVD events such as homocysteine and interleukin-6, together with increasing free testosterone and significantly preventing its progression, clearly serve to underscore the beneficial properties of physical activity and to promote its effectiveness as a support means for healthier lifestyles in the community and, particularly, among military personnel.
心血管疾病——冠心病是导致全球范围内残疾和死亡的主要原因。心血管疾病最重要的风险因素已得到充分证实，而体力活动一直被认为是干预的基石，在降低这种疾病的负担方面具有极其重要的作用。本研究旨在探讨健康新兵的活动和不活动与非脂类心血管疾病危险因素之间的关系。
通过问卷，在两组（活动组=50 人，不活动组=50 人）中随机匹配，评估了选定的激素和变量，如睾酮、游离睾酮、维生素 D、同型半胱氨酸、叶酸，以及炎症细胞因子，如 hsCRP、TNF-α 和 IL-6。使用简单相关程序确定一些测量变量与心血管疾病危险因素之间的关系。
体力活动组的同型半胱氨酸（14.3±1.9 与 16.5±3.7，p<0.000）和白细胞介素-6（2.9±5.3 与 6±8.2，p<0.025）水平明显较低，游离睾酮水平也有升高的趋势（13.1±7.1 与 11±5.3，p=0.08）。BMI、WC、tHcy 与相应的危险因素之间存在显著相关性；hsCRP 和 IL-6 之间以及 TT 和 FT 之间也存在显著相关性。
降低同型半胱氨酸和白细胞介素-6 等心血管疾病事件的危险因素，同时增加游离睾酮并显著预防其进展，显然有助于强调体力活动的有益特性，并促进其作为社区更健康生活方式的支持手段的有效性，特别是在军人中。
