Wolfsen A R, Odell W D
Am J Med. 1979 May;66(5):765-72. doi: 10.1016/0002-9343(79)91114-8.
ProACTH was identified by radioimmunoassay and column chromatography in extracts of 38 lung carcinomas. One hundred patients were evaluated because of abnormalities on chest roentgenograms; 53 (72 per cent) of 74 with lung cancers had increased plasma ACTH immunoreactivity; all 26 with benign abnormalities had normal ACTH. Of 101 patients with obstructive lung disease, five of 20 with elevated plasma ACTH levels and two of 81 with normal plasma ACTH levels had lung cancer within two years. In three of 31 patients with granulomatous lung disease plasma ACTH levels were elevated during acute exacerbation of the disease, but they returned to normal after recovery. We conclude that plasma ACTH immunoreactivity is frequently increased early in the course of lung carcinoma.
通过放射免疫测定法和柱色谱法在38例肺癌提取物中鉴定出促肾上腺皮质激素原（ProACTH）。100例患者因胸部X线片异常而接受评估；74例肺癌患者中有53例（72%）血浆促肾上腺皮质激素免疫反应性升高；26例良性异常患者的促肾上腺皮质激素均正常。在101例阻塞性肺病患者中，20例血浆促肾上腺皮质激素水平升高的患者中有5例，81例血浆促肾上腺皮质激素水平正常的患者中有2例在两年内患肺癌。在31例肉芽肿性肺病患者中，3例在疾病急性加重期血浆促肾上腺皮质激素水平升高，但恢复后恢复正常。我们得出结论，血浆促肾上腺皮质激素免疫反应性在肺癌病程早期经常升高。
