Chretien M F, Pouplard-Barthelaix A, Dubois M P, Simard C, Rèbel A
J Clin Pathol. 1986 Apr;39(4):418-22. doi: 10.1136/jcp.39.4.418.
The immunocytological detection of adrenocorticotrophic hormone (ACTH) and somatotropin release inhibitor factor (SRIF) like immunoreactivity was carried out on tumour cells from bronchial brush smears in 39 cases of lung tumours. Results obtained were compared with the cytological and histological diagnosis and confirmed the high incidence of ACTH synthesis by malignant bronchial carcinoma cells: the same phenomenon also seems to occur for somatostatin. The concomitant detection of ACTH and SRIF like immunoreactivity seems to be highly suggestive of small cell carcinoma and indicates that the immunocytological detection of hormones carried out at the same time as cytological examination can improve the accuracy of the diagnosis.
对39例肺肿瘤患者支气管刷检涂片的肿瘤细胞进行了促肾上腺皮质激素（ACTH）和生长抑素释放抑制因子（SRIF）样免疫反应性的免疫细胞化学检测。将所得结果与细胞学和组织学诊断进行比较，证实恶性支气管癌细胞合成ACTH的发生率很高：生长抑素似乎也存在同样的现象。ACTH和SRIF样免疫反应性的同时检测似乎强烈提示小细胞癌，并表明与细胞学检查同时进行的激素免疫细胞化学检测可提高诊断的准确性。
