Gropp C, Havemann K, Scheuer A
Cancer. 1980 Jul 15;46(2):347-54. doi: 10.1002/1097-0142(19800715)46:2<347::aid-cncr2820460223>3.0.co;2-s.
In roughly 10 patients with lung cancer of various histologic types, the levels of hormones adrenocorticotropin (ACTH), calcitonin, parathormone, beta-choriogonadotropin (HCG), human placental lactogen (HPL), growth hormone (HGH), and prolactin were determined by radioimmunoassay. The ACTH level was elevated in 30% of patients with oat cell carcinoma and in 26% of patients with large cell carcinoma. Calcitonin levels were increased in 48% of patients with oat cell carcinoma. Elevated levels of HCG were found in 33% of patients with oat cell carcinoma, in 26% of patients with large cell carcinoma, and in 19% of patients with squamous cell carcinoma. Parathormone was increased in 32% of patients with squamous cell carcinoma in 27% of patients with oat cell carcinoma, and in a few patients with large cell carcinoma. Prolactin, HCG and HPL were present only in single cases. Elevated levels of at least one hormone were found in 65.2% of all patients, and in 78% of the patients with oat cell carcinoma. Serial determinations of ACTH and calcitonin showed that these hormones are useful for monitoring therapy in lung patients. There was no relation between hormone levels and the clinical stage of disease.
对大约10例不同组织学类型的肺癌患者，采用放射免疫分析法测定了促肾上腺皮质激素（ACTH）、降钙素、甲状旁腺激素、β-绒毛膜促性腺激素（HCG）、人胎盘催乳素（HPL）、生长激素（HGH）和催乳素的水平。燕麦细胞癌患者中30%的ACTH水平升高，大细胞癌患者中26%的ACTH水平升高。燕麦细胞癌患者中48%的降钙素水平升高。燕麦细胞癌患者中33%、大细胞癌患者中26%以及鳞状细胞癌患者中19%的HCG水平升高。鳞状细胞癌患者中32%、燕麦细胞癌患者中27%以及少数大细胞癌患者的甲状旁腺激素升高。催乳素、HCG和HPL仅在个别病例中出现。所有患者中65.2%以及燕麦细胞癌患者中78%至少有一种激素水平升高。对ACTH和降钙素的连续测定表明，这些激素有助于监测肺癌患者的治疗。激素水平与疾病临床分期之间无关联。
