National Research Laboratory of Bioactive Materials, Department of Biological Engineering, Inha University, Incheon, South Korea.
Appl Microbiol Biotechnol. 2012 Jan;93(1):71-82. doi: 10.1007/s00253-011-3666-8. Epub 2011 Nov 17.
Fucoidan is a complex-sulfated polysaccharide distributed in various marine organisms, and the brown algae are reported as the major producer. The fucoidan is important for their high bioactive properties, like antibacterial, anticoagulant, antiviral, anti-tumor, etc., and many more to be explored. There is a strong archival support for the bioactivity and promising properties of this molecule, which creates a hope for this molecule as future drug against thrombosis and some kind of cancers. Reports other than the above bioactive properties have also been a matter of interest for the design of signal or enzyme-arrested new class of drugs. In the past three decades, the research on isolation, molecular characterization, and screening of biological applications has significantly increased. One major issue associated with this molecule is the higher size and seasonal variation in their chemical composition; to resolve the issue and maintain its bioactivity, a prioritized and literal hydrolysis process is required to be developed. Here, in this mini-review, we have tried to summarize the algal fucoidan research and the bioactivities influenced by their molecular size.
岩藻聚糖是一种分布在各种海洋生物中的复杂硫酸多糖，褐藻被报道为主要的生产者。岩藻聚糖因其具有高生物活性而重要，如抗菌、抗凝、抗病毒、抗肿瘤等，还有更多有待探索。该分子具有强大的生物活性和有前途的特性，这为其作为未来抗血栓和某些癌症药物创造了希望。除了上述生物活性特性外，该分子作为信号或酶抑制剂的新型药物的设计也引起了人们的关注。在过去的三十年中，对分离、分子特征和生物应用筛选的研究显著增加。与该分子相关的一个主要问题是其化学组成的较大尺寸和季节性变化；为了解决这个问题并保持其生物活性，需要开发一种优先和直接的水解过程。在这篇迷你综述中，我们试图总结藻类岩藻聚糖的研究及其分子大小对生物活性的影响。
