Zahariev Nikolay, Katsarov Plamen, Lukova Paolina, Pilicheva Bissera
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, 4002 Plovdiv, Bulgaria.
Research Institute, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, 4002 Plovdiv, Bulgaria.
Polymers (Basel). 2023 Jul 29;15(15):3242. doi: 10.3390/polym15153242.
Fucoidan belongs to the family of marine sulfated, L-fucose-rich polysaccharides found in the cell wall matrix of various brown algae species. In the last few years, sulfated polysaccharides have attracted the attention of researchers due to their broad biological activities such as anticoagulant, antithrombotic, antidiabetic, immunomodulatory, anticancer and antiproliferative effects. Recently the application of fucoidan in the field of pharmaceutical technology has been widely investigated. Due to its low toxicity, biocompatibility and biodegradability, fucoidan plays an important role as a drug carrier for the formulation of various drug delivery systems, especially as a biopolymer with anticancer activity, used for targeted delivery of chemotherapeutics in oncology. Furthermore, the presence of sulfate residues with negative charge in its structure enables fucoidan to form ionic complexes with oppositely charged molecules, providing relatively easy structure-forming properties in combination with other polymers. The aim of the present study was to overview essential fucoidan characteristics, related to its application in the development of pharmaceutical formulations as a single drug carrier or in combinations with other polymers. Special focus was placed on micro- and nanosized drug delivery systems with polysaccharides and their application in the field of oncology.
岩藻依聚糖属于海洋硫酸化、富含L-岩藻糖的多糖家族，存在于各种褐藻物种的细胞壁基质中。在过去几年中，硫酸化多糖因其广泛的生物活性，如抗凝、抗血栓形成、抗糖尿病、免疫调节、抗癌和抗增殖作用，而吸引了研究人员的关注。最近，岩藻依聚糖在制药技术领域的应用受到了广泛研究。由于其低毒性、生物相容性和生物降解性，岩藻依聚糖作为各种药物递送系统制剂的药物载体发挥着重要作用，尤其是作为一种具有抗癌活性的生物聚合物，用于肿瘤学中化疗药物的靶向递送。此外，其结构中带负电荷的硫酸根残基的存在，使岩藻依聚糖能够与带相反电荷的分子形成离子复合物，与其他聚合物结合时具有相对容易形成结构的特性。本研究的目的是概述岩藻依聚糖的基本特性，这些特性与其作为单一药物载体或与其他聚合物组合在药物制剂开发中的应用有关。特别关注了多糖的微米级和纳米级药物递送系统及其在肿瘤学领域的应用。
