Marine College, Shandong University, Weihai 264209, China.
School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Mar Drugs. 2019 Mar 20;17(3):183. doi: 10.3390/md17030183.
The marine acid polysaccharide fucoidan has attracted attention from both the food and pharmaceutical industries due to its promising therapeutic effects. Fucoidan is a polysaccharide that mainly consists of L-fucose and sulphate groups. Its excellent biological function is attributed to its unique biological structure. Classical activities include antitumor, antioxidant, anticoagulant, antithrombotic, immunoregulatory, antiviral and anti-inflammatory effects. More recently, fucoidan has been shown to alleviate metabolic syndrome, protect the gastrointestinal tract, benefit angiogenesis and bone health. This review focuses on the progress in our understanding of the biological activities of fucoidan, highlighting its benefits for the treatment of human disease. We hope that this review can provide some theoretical basis and inspiration for the product development of fucoidan.
海洋酸性多糖岩藻聚糖因其有希望的治疗效果而引起了食品和制药行业的关注。岩藻聚糖是一种主要由 L-岩藻糖和硫酸基团组成的多糖。其优异的生物功能归因于其独特的生物结构。经典的活性包括抗肿瘤、抗氧化、抗凝、抗血栓、免疫调节、抗病毒和抗炎作用。最近，岩藻聚糖已被证明可缓解代谢综合征，保护胃肠道，有益于血管生成和骨骼健康。本综述重点介绍了我们对岩藻聚糖生物活性的理解进展，强调了其对人类疾病治疗的益处。我们希望本综述能为岩藻聚糖产品的开发提供一些理论依据和启示。
