Department of Rheumatology, King's College London, Weston Education Centre, Denmark Hill, 10 Cutcombe Road, London SE5 9RJ, UK.
J Rheumatol. 2012 Jan;39(1):28-31. doi: 10.3899/jrheum.110668. Epub 2011 Nov 15.
We evaluated the influence of demographic and clinical factors on pain thresholds in patients with rheumatoid arthritis (RA).
A cross-sectional observational study (105 patients with RA) assessed pain thresholds using an algometer. Regression analysis examined the influence of demographic and clinical assessments.
Pain thresholds (median 289, interquartile range 89-434) correlated with assessments of disease activity (tender joint counts), disability (Health Assessment Questionnaire), fatigue, depression, and anxiety. Ordinal logistic regression showed tender point counts and disease duration were the dominant contributors.
These findings suggest that low pain thresholds reflect "fibromyalgic" RA (many tender points) and central pain sensitization with prolonged disease duration.
我们评估了人口统计学和临床因素对类风湿关节炎（RA）患者痛阈的影响。
一项横断面观察性研究（105 例 RA 患者）使用压力计评估痛阈。回归分析检查了人口统计学和临床评估的影响。
痛阈（中位数 289，四分位距 89-434）与疾病活动度（压痛关节计数）、残疾（健康评估问卷）、疲劳、抑郁和焦虑评估相关。有序逻辑回归显示压痛点计数和疾病持续时间是主要的影响因素。
这些发现表明，低痛阈反映了“纤维肌痛样”RA（许多压痛点）和中央痛觉敏感，与疾病持续时间延长有关。
