Taylor Clive R
Department of Pathology, HMR, Keck School of Medicine, University of Southern California, Zonal Avenue, Los Angeles, CA 90033, USA.
Appl Immunohistochem Mol Morphol. 2011 Dec;19(6):491-3. doi: 10.1097/PAI.0b013e318229ffd6.
In the year 1850, microscopes had evolved in quality to the point that the "first pathologists emerged from the treacherous swamps of medieval practice onto the relatively firm ground that histopathology seemed to offer." These early pathologists began to practice the art of image analysis, and diagnostic surgical pathology was born. Today the traditional microscope, in the hands of an experienced pathologist, is established as the gold standard for diagnosis of cancer and other diseases. Nonetheless, it is a tool and a technology that is more than 150 years old. Rapid advances in the capabilities of digital imaging hardware and software now offer the real possibility of moving to a new level of practice, using whole slide digital images for diagnosis, education, and research in morphologic pathology. Potential efficiencies in work flow and diagnostic integration, coupled with the use of powerful new analytic methods, promise radically to change the future shape of surgical pathology.
1850年，显微镜的质量已经发展到这样一个程度，即“第一批病理学家从中世纪实践的 treacherous swamps 中走出，踏上了组织病理学似乎提供的相对坚实的土地”。这些早期病理学家开始实践图像分析技术，诊断性外科病理学由此诞生。如今，在经验丰富的病理学家手中，传统显微镜已成为诊断癌症和其他疾病的金标准。然而，它是一种已有150多年历史的工具和技术。数字成像硬件和软件功能的迅速发展，现在为迈向新的实践水平提供了切实可能性，即使用全切片数字图像进行形态病理学的诊断、教育和研究。工作流程和诊断整合方面的潜在效率提升，再加上使用强大的新分析方法，有望从根本上改变外科病理学的未来形态。
