印度迈索尔年轻女性原发性不孕的流行率及相关因素。
Prevalence & correlates of primary infertility among young women in Mysore, India.
机构信息
School of Medicine, University of California, San Francisco, CA, USA.
出版信息
Indian J Med Res. 2011 Oct;134(4):440-6.
BACKGROUND & OBJECTIVES: There are sparse data on the prevalence of primary infertility in India and almost none from Southern India. This study describes the correlates and prevalence of primary infertility among young women in Mysore, India.
METHODS
The baseline data were collected between November 2005 through March 2006, among 897 sexually active women, aged 15-30 yr, for a study investigating the relationship of bacterial vaginosis and acquisition of herpes simplex virus type-2 (HSV-2) infection. A secondary data analysis of the baseline data was undertaken. Primary infertility was defined as having been married for longer than two years, not using contraception and without a child. Logistic regression was used to examine factors associated with primary infertility.
RESULTS
The mean age of the women was 25.9 yr (range: 16-30 yr) and the prevalence of primary infertility was 12.6 per cent [95% Confidence Interval (CI): 10.5-15.0%]. The main factor associated with primary infertility was HSV-2 seropositivity (adjusted odds ratio: 3.41; CI: 1.86, 6.26).
INTERPRETATION & CONCLUSIONS: The estimated prevalence of primary infertility among women in the study was within the range reported by the WHO and similar to other estimates from India. Further research is needed to examine the role of HSV-2 in primary infertility.
背景与目的
印度原发性不孕的流行情况数据稀疏，来自印度南部的情况则几乎没有。本研究描述了印度迈索尔年轻女性原发性不孕的相关因素和流行情况。
方法
本研究的基线数据收集于 2005 年 11 月至 2006 年 3 月之间，共纳入 897 名 15-30 岁的有性行为的女性，她们参与了一项研究，旨在调查细菌性阴道病与单纯疱疹病毒 2 型（HSV-2）感染获得之间的关系。对基线数据进行了二次数据分析。原发性不孕定义为结婚超过两年，未采取避孕措施且没有孩子的情况。采用逻辑回归分析与原发性不孕相关的因素。
结果
这些女性的平均年龄为 25.9 岁（范围：16-30 岁），原发性不孕的患病率为 12.6%（95%置信区间：10.5-15.0%）。与原发性不孕主要相关的因素是 HSV-2 血清阳性（调整后的优势比：3.41；95%置信区间：1.86，6.26）。
解释与结论
本研究中女性原发性不孕的估计患病率在世界卫生组织报告的范围内，与印度其他类似的估计值相近。需要进一步研究 HSV-2 在原发性不孕中的作用。
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