Department of Orthopaedics, University of North Carolina School of Medicine, Chapel Hill, NC 37599-7055, USA.
J Orthop Trauma. 2011 Dec;25(12):756-61. doi: 10.1097/BOT.0b013e318211363a.
We investigated the role of negative pressure therapy (NPT) in postoperative primary wound treatment and closure. To date, extensive evidence exists demonstrating the benefit of negative pressure dressings in the treatment of open wounds; our experiment tested the hypothesis that negative pressure dressings improve healing of closed (sutured) wounds.
A porcine model was used to collect data on the characteristics of closed wounds after 3 days of treatment with NPTs as compared with control dressings.
In six pigs with a total of 56 wounds, load to failure (N/mm) in controls was 0.348 (standard deviation [SD] 0.109) versus NPT at 0.470 (SD, 0.194) with a P value of 0.001; energy to failure (mJ/mm) in controls was 0.85 (SD, 0.378) versus NPT at 1.128 (SD, 0.638) with a P value of 0.035. Blinded grading of clinical wound appearance and cross-sectional hematoma size were also improved at 72 hours.
NPT dressings applied to surgically closed wounds enhance the healing characteristics of porcine wounds at 3 days.
We have observed that primarily closed surgical wounds may benefit from treatment with NPT. The benefit of using NPTs may be most pronounced in situations in which wounds are closed under tension, involve considerable soft tissue trauma, or may be at risk of subdermal hematoma formation.
我们研究了负压治疗（NPT）在术后初次伤口处理和闭合中的作用。迄今为止，大量证据表明负压敷料在开放性伤口治疗中的有益作用；我们的实验检验了一个假设，即负压敷料可改善闭合（缝合）伤口的愈合。
使用猪模型收集 3 天 NPT 治疗与对照敷料相比闭合伤口特征的数据。
在 6 头猪共 56 个伤口中，对照组的失效负载（N/mm）为 0.348（标准差[SD] 0.109），而 NPT 为 0.470（SD，0.194），P 值为 0.001；对照组的失效能量（mJ/mm）为 0.85（SD，0.378），NPT 为 1.128（SD，0.638），P 值为 0.035。72 小时时，临床伤口外观和横截面血肿大小的盲法分级也得到改善。
NPT 敷料应用于手术闭合伤口可增强猪伤口在 3 天时的愈合特征。
我们观察到，原发性闭合性手术伤口可能受益于 NPT 治疗。在伤口在张力下闭合、涉及大量软组织创伤或可能有皮下血肿形成风险的情况下，使用 NPT 的益处可能最为明显。
