Department of Medicine, University of California, Irvine, CA, USA.
J Clin Rheumatol. 2011 Dec;17(8):429-31. doi: 10.1097/RHU.0b013e31823b0ca5.
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by arterial and venous thrombotic events associated with antiphospholipid antibodies. Antiphospholipid syndrome is commonly seen with collagen vascular diseases; however, other entities that can cause APS include chronic viral infections, certain medications, and malignancies. We present an interesting patient with an atypical presentation and course of presumed APS, which lead us to perform an exhaustive search for a secondary cause. The patient was ultimately found to have splenic marginal zone lymphoma. Analysis of the current data in the literature is presented for APS, antiphospholipid antibodies, and malignancy. Based on the literature findings and our experience, we recommend a thorough and repeated evaluation for an underlying malignancy in patients who have an atypical presentation and features of APS.
抗磷脂综合征（APS）是一种自身免疫性疾病，其特征是存在抗磷脂抗体相关的动脉和静脉血栓事件。APS 常见于胶原血管疾病；然而，其他可能导致 APS 的实体包括慢性病毒感染、某些药物和恶性肿瘤。我们呈现了一位具有非典型表现和疑似 APS 病程的有趣患者，这促使我们进行了详尽的继发性病因搜索。最终发现该患者患有脾边缘区淋巴瘤。本文呈现了 APS、抗磷脂抗体和恶性肿瘤的当前文献数据的分析。根据文献研究结果和我们的经验，我们建议对具有非典型表现和 APS 特征的患者进行彻底和重复的潜在恶性肿瘤评估。
