Department of Nephrology, First Faculty of Medicine, University of Rome La Sapienza, Viale dell'Università, 37 IT-00185 Rome, Italy.
Am J Nephrol. 2009;30(5):405-12. doi: 10.1159/000235941. Epub 2009 Aug 28.
Antiphospholipid antibodies are a heterogeneous group of autoantibodies associated with the hypercoagulable state affecting all vascular districts with thrombosis named antiphospholipid syndrome (APS). APS is an autoimmune disease with multifactorial etiology that includes cellular, molecular, genetic and pathogenic mechanisms. The APS clinical features are a combination of arterial and/or venous thrombosis, hematological events, recurrent fetal losses, neurological disorders and intra-abdominal manifestations. The renal involvement is associated with both primary and secondary APS. Clinical features include hypertension, renal artery stenosis, thrombotic microangiopathy and other histological manifestations of the nephropathy (APSN), venous renal thrombosis, APSN in the course of systemic lupus erythematosus and renal failure. APSN is an independent risk factor that should be included in the classification criteria for definite APS with characteristic clinical and histological features.
抗磷脂抗体是一组与影响所有血管区域的血栓形成的高凝状态相关的自身抗体，称为抗磷脂综合征 (APS)。APS 是一种具有多因素病因的自身免疫性疾病，包括细胞、分子、遗传和发病机制。APS 的临床特征是动脉和/或静脉血栓形成、血液事件、反复胎儿丢失、神经障碍和腹内表现的组合。肾脏受累与原发性和继发性 APS 均有关。临床特征包括高血压、肾动脉狭窄、血栓性微血管病和肾脏病 (APSN)的其他组织学表现、静脉肾血栓形成、系统性红斑狼疮和肾功能衰竭过程中的 APSN。APSN 是一个独立的危险因素，应包含在具有特征性临床和组织学特征的明确 APS 的分类标准中。
