Service de Médecine Interne, Centre Hospitalier Universitaire Hôtel-Dieu, Nantes, France.
J Clin Rheumatol. 2011 Dec;17(8):439-41. doi: 10.1097/RHU.0b013e31823a58d7.
By contrast to cryoglobulinemic vasculitis, polyarteritis nodosa associated with hepatitis C virus (HCV) infection is rare and still a controversial entity. The best treatment for this condition is not established. Cases reported in the literature have been treated with various combinations of corticosteroids, antiviral therapy, and immunosuppressants. We report a case of severe life-threatening HCV-associated polyarteritis nodosa successfully treated with rituximab and a short course of corticosteroids without antiviral therapy. This case, along with recently published data, emphasizes the value of B-cell-targeted therapy in this unusual form of HCV-associated vasculitis.
与冷球蛋白血症性血管炎相反，丙型肝炎病毒 (HCV) 感染相关的多动脉炎结节症较为罕见，仍然存在争议。这种疾病的最佳治疗方法尚未确定。文献中报道的病例采用了各种皮质类固醇、抗病毒治疗和免疫抑制剂的联合治疗。我们报告了一例严重危及生命的 HCV 相关多动脉炎结节症病例，成功地使用利妥昔单抗和短期皮质类固醇治疗，而未进行抗病毒治疗。这例病例以及最近发表的数据强调了针对 B 细胞的靶向治疗在这种不寻常的 HCV 相关血管炎中的价值。
